FlyBase Allele Report: Dmel\E(z)[731]

General Information

Symbol

Dmel\E(z)⁷³¹

Species

D. melanogaster

Name

FlyBase ID

FBal0141835

Feature type

allele

Associated gene

Dmel\E(z)

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(de Ayala Alonso et al., 2007, Muller et al., 2002)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A.

(Muller et al., 2002)

Amino acid replacement: W638term.

(Muller et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:10,635,007..10,635,007 [-]

Nucleotide change:

G10635007A

Reported nucleotide change:

G?A

Amino acid change:

W638term | E(z)-PA; W638term | E(z)-PB; W643term | E(z)-PC

Reported amino acid change:

W638term

Comment:

TGG to TGA

(Muller et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Delta^UAS.cDa, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Song et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | somatic clone

(Bello et al., 2007)

abnormal neuroanatomy | somatic clone

(Wang et al., 2006)

bang sensitive (with E(z)⁶³), with E(z)^{A691G.αTub84B.EGFP}

(Jangam et al., 2023)

decreased cell number | somatic clone

(Bello et al., 2007)

fertile (with E(z)⁶³), with E(z)^{A691G.αTub84B.EGFP}

(Jangam et al., 2023)

fertile (with E(z)⁶³), with E(z)^{αTub84B.EGFP}

(Jangam et al., 2023)

homeotic | somatic clone

(Pengelly et al., 2013)

increased cell number | male | heat sensitive (with E(z)⁶¹)

(Eun et al., 2014)

increased occurrence of cell division | male | heat sensitive (with E(z)⁶¹)

(Eun et al., 2014)

lethal (with E(z)⁶³)

(Jangam et al., 2023)

short lived (with E(z)⁶³), with E(z)^{A691G.αTub84B.EGFP}

(Jangam et al., 2023)

short lived (with E(z)⁶³), with E(z)^{αTub84B.EGFP}

(Jangam et al., 2023)

visible | somatic clone

(de Ayala Alonso et al., 2007)

Phenotype Manifest In

abdominal tergite 4 (with E(z)⁶³), with E(z)^{A691G.αTub84B.EGFP}

(Jangam et al., 2023)

axon | somatic clone

(Wang et al., 2006)

CNS glial cell | ectopic | somatic clone

(Wang et al., 2006)

cyst progenitor cell | increased number | heat sensitive (with E(z)⁶¹)

(Eun et al., 2014)

leg (with E(z)⁶³), with E(z)^{A691G.αTub84B.EGFP}

(Jangam et al., 2023)

male germline cell | heat sensitive (with E(z)⁶¹)

(Eun et al., 2014)

neuroblast | somatic clone

(Bello et al., 2007)

sex comb | adult stage | ectopic (with E(z)⁶³), with E(z)^{A691G.αTub84B.EGFP}

(Jangam et al., 2023)

testis | heat sensitive (with E(z)⁶¹)

(Eun et al., 2014)

wing | somatic clone

(de Ayala Alonso et al., 2007)

Detailed Description

Statement

Reference

E(z)⁷³¹/+ testes do not show a germline stem cell-like tumor phenotype.

(Feng et al., 2017)

E(z)⁷³¹ mutant clones show homeotic transformation into more posterior body segments; the mutant sensory bristles are finer and more tapered than the neighbouring wild type bristles in A2 and resemble bristles characteristic of abdominal segment A10 in wild type animals.

(Pengelly et al., 2013)

Homozygous neuroblast clones in the third larval instar central brain and ventral ganglion are dramatically reduced in size compared to control clones and show a dramatic reduction in mitotic activity.

(Bello et al., 2007)

Homozygous clones in the wing result in an overall reduction in wing size, indicating partial transformation to haltere, and blisters and necrotic tissue are seen in the wing blade.

(de Ayala Alonso et al., 2007)

E(z)⁷³¹ mosaic brains show misguided axons and ectopic gila-like cells.

(Wang et al., 2006)

Homozygous clones in the imaginal disc have no obvious proliferation defects.

(Muller et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

E(z)⁷³¹/E(z)⁶¹ has increased cell number | male | heat sensitive phenotype, suppressible by Egfr^f2

(Eun et al., 2014)

Enhancer of

Statement

Reference

E(z)⁷³¹ is an enhancer of increased cell number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

E(z)[+]/E(z)⁷³¹ is an enhancer of neoplasia | spermatogenesis phenotype of E(Pc)^GL00169, Scer\GAL4^NP1624

(Feng et al., 2017)

E(z)[+]/E(z)⁷³¹ is an enhancer of visible | dominant phenotype of gcm^Pyx

(Popkova et al., 2012)

Suppressor of

Statement

Reference

E(z)⁷³¹ is a suppressor of visible phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Anderson et al., 2011)

E(z)[+]/E(z)⁷³¹ is a suppressor of neoplasia phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

E(z)[+]/E(z)⁷³¹ is a suppressor of visible phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

Phenotype Manifest In

Suppressed by

Statement

Reference

E(z)⁷³¹/E(z)⁶¹ has cyst progenitor cell | increased number | heat sensitive phenotype, suppressible by Egfr^f2

(Eun et al., 2014)

E(z)⁷³¹/E(z)⁶¹ has testis | heat sensitive phenotype, suppressible by Egfr^f2

(Eun et al., 2014)

Enhancer of

Statement

Reference

E(z)⁷³¹ is an enhancer of type II neuroblast | increased number phenotype of numb^Ex112/numb¹⁵

(Rajan et al., 2023)

E(z)[+]/E(z)⁷³¹ is an enhancer of sex comb tooth | ectopic phenotype of Psc¹

(Nishioka et al., 2018)

E(z)[+]/E(z)⁷³¹ is an enhancer of male germline stem cell | increased number phenotype of E(Pc)^GL00169, Scer\GAL4^NP1624

(Feng et al., 2017)

E(z)[+]/E(z)⁷³¹ is an enhancer of chaeta | increased number phenotype of gcm^Pyx

(Popkova et al., 2012)

Suppressor of

Statement

Reference

E(z)⁷³¹ is a suppressor of eye phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Anderson et al., 2011)

E(z)[+]/E(z)⁷³¹ is a suppressor of eye | somatic clone phenotype of Utx¹

(Herz et al., 2010)

E(z)[+]/E(z)⁷³¹ is a suppressor of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic sex comb teeth phenotype of Psc¹ heterozygous males is exacerbated by heterozygosity for E(z)⁷³¹.

(Nishioka et al., 2018)

The disorganised eye phenotype caused by expression of sens^Scer\UAS.cNa under the control of Scer\GAL4^lz-gal4 is suppressed by E(z)⁷³¹.

(Anderson et al., 2011)

Heterozygosity for E(z)⁷³¹ suppresses the over-representation phenotype of Utx¹ mosaics.

(Herz et al., 2010)

E(z)⁷³¹ dominantly suppresses the eye tumour phenotype of flies expressing Dl^Scer\UAS.cDa under the control of Scer\GAL4^ey.PH and also carrying the P{GSV1}lola^GS88A8 insertion (which results in the lola^GS88A8 and psq^GS88A8 alleles being expressed under the control of Scer\GAL4^ey.PH).