FlyBase Allele Report: Dmel\exex[UAS.cBa]

General Information

Symbol

Dmel\exex^UAS.cBa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Broihier

FlyBase ID

FBal0137266

Feature type

allele

Associated gene

Dmel\exex

Associated Insertion(s)

Carried in Construct

P{UAS-exex.B}

Also Known As

UAS-hb9

Key Links

Transgenic product class

wild_type

(Broihier and Skeath, 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Broihier and Skeath, 2002)

Mutagen

in vitro construct

(Skeath, 2007.3.20, Broihier and Skeath, 2002)

Progenitor genotype

Carried in construct

P{UAS-exex.B}

Cytology

Description

Expression of full length exex coding region is governed by UASt regulatory sequences.

(Broihier and Skeath, 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

exex

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Broihier and Skeath, 2002)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav-C155

(Lacin et al., 2014)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^en-e16E

(Lacin et al., 2014)

Phenotype Manifest In

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Broihier and Skeath, 2002)

neuron | embryonic stage | lateral, with Scer\GAL4^elav-C155

(Lacin et al., 2014)

neuron | embryonic stage | lateral, with Scer\GAL4^en-e16E

(Lacin et al., 2014)

presumptive embryonic/larval central nervous system, with Scer\GAL4^elav.PLu

(Broihier et al., 2004)

Detailed Description

Statement

Reference

Expression of exex^Scer\UAS.cBa under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^en-e16E results in the formation of ectopic embryonic lateral fd59A[+] neurons.

(Lacin et al., 2014)

The central nervous system of stage 15 vnd^Scer\UAS.cMa; Scer\GAL4^elav.PLu embryos has reduced numbers of vnd expressing neurons.

(Broihier et al., 2004)

When expression is driven by Scer\GAL4^elav-C155, all motor axons fuse with the ISN before exiting the CNS. Dorsally, ISNs truncate prematurely or branch aberrantly.

(Broihier and Skeath, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav-C155, exex^UAS.cBa has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by HGTX^UAS.cBa, Scer\GAL4^elav-C155

(Lacin et al., 2014)

Scer\GAL4^elav-C155, exex^UAS.cBa has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by HGTX^D25

(Lacin et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav-C155, exex^UAS.cBa has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by HGTX^UAS.cBa, Scer\GAL4^elav-C155

(Lacin et al., 2014)

Scer\GAL4^elav-C155, exex^UAS.cBa has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by HGTX^D25

(Lacin et al., 2014)

NOT Suppressor of

Statement

Reference

exex^UAS.cBa, Scer\GAL4^ppk.PU is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Hsap\ATXN3^{tr.Q70.cc0.UAS.Tag:HA,Tag:MYC}, Scer\GAL4^ppk.PU

(Kwon et al., 2018)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav-C155, exex^UAS.cBa has neuron | embryonic stage | lateral phenotype, non-enhanceable by HGTX^UAS.cBa, Scer\GAL4^elav-C155

(Lacin et al., 2014)

Scer\GAL4^elav-C155, exex^UAS.cBa has neuron | embryonic stage | lateral phenotype, non-enhanceable by HGTX^D25

(Lacin et al., 2014)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav-C155, exex^UAS.cBa has neuron | lateral | embryonic stage phenotype, non-suppressible by HGTX^UAS.cBa, Scer\GAL4^elav-C155

(Lacin et al., 2014)

Scer\GAL4^elav-C155, exex^UAS.cBa has neuron | lateral | embryonic stage phenotype, non-suppressible by HGTX^D25

(Lacin et al., 2014)

NOT Suppressor of

Statement

Reference

exex^UAS.cBa, Scer\GAL4^ppk.PU is a non-suppressor of larval multidendritic class IV neuron | third instar larval stage phenotype of Hsap\ATXN3^{tr.Q70.cc0.UAS.Tag:HA,Tag:MYC}, Scer\GAL4^ppk.PU

(Kwon et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of HGTX^Scer\UAS.cBa does not alter the ectopic lateral fd59A[+] neurons seen when exex^Scer\UAS.cBa is expressed under the control of Scer\GAL4^elav-C155.

A homozygous HGTX^D25 mutant background does not alter the ectopic lateral fd59A[+] neurons seen when exex^Scer\UAS.cBa is expressed under the control of Scer\GAL4^elav-C155.

(Lacin et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9929

w^*; P{UAS-exex.B}H1/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

exex^Scer\UAS.cBa

exex^UAS.cBa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Broihier

(Broihier and Skeath, 2002)

Secondary FlyBase IDs

References (7)

Report Sections

Open Close