FB2024_03 , released June 25, 2024
Allele: Dmel\kkvDZ8
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General Information
Symbol
Dmel\kkvDZ8
Species
D. melanogaster
Name
FlyBase ID
FBal0137224
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Cytology
Description

Amino acid replacement: W961term.

Nucleotide substitution: G?A.

Amino acid replacement: W947term.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G5382259A

Reported nucleotide change:

G?A

Amino acid change:

W961term | kkv-PA; W961term | kkv-PC; W961term | kkv-PD

Reported amino acid change:

W961term

Comment:

TGG to TAG.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

At the end of embryogenesis, kkvDZ8 mutant embryos exhibit severe tube dilations and cysts in all multicellular branches of the tracheal system. In addition, the ganglionic branches show discontinuities at the borders of the ventral nerve cord. However, branching of the tracheal system appears normal.

Homozygous embryos fail to hatch but are initially hyperactive, often reversing themselves within the eggshell (7.8% of embryos show this "retroactive" phenotype). When the embryos are mechanically devitellinised the resulting cuticle preparations stretch to a much greater extent than wild-type cuticles, resulting in inflated cuticles ("blimp" phenotype). Embryos have defects in the head skeleton and slight denticle belt abnormalities.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments

kkvDZ8 fails to complement lethality and tracheal phenotypes due to kkvs017909.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)