FB2024_03 , released June 25, 2024
Allele: Dmel\Fmr1EP3422
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General Information
Symbol
Dmel\Fmr1EP3422
Species
D. melanogaster
Name
FlyBase ID
FBal0131030
Feature type
allele
Associated gene
Dmel\Fmr1
Associated Insertion(s)
P{EP}Fmr1EP3422
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Zhang et al., 2001)
Mutagen
P-element activity
(Dockendorff et al., 2002, Inoue et al., 2002, Gene Disruption Project members, 2001-, Zhang et al., 2001)
Progenitor genotype
Associated Insertion(s)
P{EP}Fmr1EP3422
Cytology
Description

Insertion of P{EP} into 5' UTR of Fmr1, in the opposite orientation to Fmr1.

(Dockendorff et al., 2002)

Insertion of P{EP} into an intron between two 5' non-coding exons of the Fmr1 transcription unit.

(Zhang et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  fragile X syndrome
      CEA
      (Zhang et al., 2001)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When expression is driven by Scer\GAL4tim.PE, flies show no alteration to arrhythmicity or period.

      (Dockendorff et al., 2002)

      Mutants show no morphological defects. When tested for bang sensitivity, temperature sensitivity and phototaxis there is no detectable difference between wild type and mutant. However there are defects in coordination in a simple flight test.

      (Zhang et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Fmr1EP3422
      Name Synonyms
      Secondary FlyBase IDs
        References (5)