FB2024_03 , released June 25, 2024
Allele: Dmel\TppIIk14301
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General Information
Symbol
Dmel\TppIIk14301
Species
D. melanogaster
Name
FlyBase ID
FBal0128049
Feature type
allele
Associated gene
Dmel\TppII
Associated Insertion(s)
P{lacW}Nrkk14301
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}Nrkk14301
Cytology
Description

P{lacW} insertion in intron 1.

(Schnorr et al., 2001)

The P{lacW}Nrkk14301 insertion maps within both TppII and CG34439 (overlapping genes on opposite strands) by BLAST analysis of the flanking sequence of the insertion. In addition, in FBrf0139680, the P{lacW}Nrkk14301 insertion is stated to map "within the 5' end of an alternative-splice form of Nrk" (Nrk is located downstream to CG34439, and overlaps it on the same strand).

(FlyBase, 1996-)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The P{lacW}Nrkk14301 insertion (which is inserted into 2 overlapping genes; intron 1 of TppII and exon 1 of Nrk) is a moderate dominant enhancer of the Ras85Dix12a eggshell phenotype; 31-40% of dorsal appendages are wild type.

      (Schnorr et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

      Complements: Aats-val03531. Complements: Aats-valk14312. Complements: Aats-valk14804. Complements: Aats-valrI255. Complements: Aats-valrQ802.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TppIIk14301
      l(2)k14301
      (Schnorr et al., 2001)
      l(2)k14301k14301
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0064109
      References (3)