FB2024_03 , released June 25, 2024
Allele: Dmel\jeb-c1
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General Information
Symbol
Dmel\jeb-c1
Species
D. melanogaster
Name
FlyBase ID
FBal0127957
Feature type
allele
Associated gene
Dmel\jeb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Weiss et al., 2001)
Progenitor genotype
jebk05644
(Weiss et al., 2001)
Cytology
Description

Excision of the P{lacW} element.

(Weiss et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous jeb-c1 mutant longitudinal visceral muscle (LVM) founder cells in stage 12 embryos migrate normally towards the trunk visceral mesoderm (TVM) and very few dying cells are seen. At stage 13 the front migrating cells reach the anterior end of the trunk visceral mesoderm as in wild type. However during late stage 13 the migration becomes disordered and progressive founder cell death is seen.

      (Reim et al., 2012)

      jeb-c1 mutants show a salivary gland phenotype. At stage 14, mutant salivary glands remain associated with the inner circular muscle layer, while in wild type, these structures become separate. After stage 15, cells from the distal tips of the jeb-c1 salivary glands spread into the region of the undifferentiated midgut that forms the gastric caecae in the wild-type embryos. The mutant glands become mispositioned and/or elongated and maintain contact with the area of the midgut immediately adjacent to the proventriculus.

      (Vining et al., 2005)

      Marker analysis indicates that no visceral muscle founders are specified in jeb-c1 mutant embryos. Myoblasts do form in the visceral mesoderm of these embryos, but these cells fuse with somatic muscle founders (i.e.- they are still fusion competent). The resulting animals exhibit loss of visceral musculature, but have normal somatic muscle patterning.

      (Lee et al., 2003)

      Differentiated visceral mesoderm is not seen in mutant embryos, although other mesodermal tissues (somatic muscles, heart, fat body and hemocytes) develop normally. Visceral mesoderm precursor cells are specified but fail to migrate normally. There is an increase in the number of nuclei in positions consistent with an increase in somatic muscle precursors, but there is no major disruption of somatic muscle patterning. The midgut endoderm is specified normally and migrates to form two longitudinal bands. Subsequent dorsal and ventral endoderm migration is abnormal (probably because this migration depends on the visceral mesoderm).

      (Weiss et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      jeb-c1 has muscle founder cell & visceral mesoderm phenotype, suppressible by Scer\GAL4bap.3/Alk::Hsap\NPM1UAS.act

      (Lee et al., 2003)

      jeb-c1 has visceral mesoderm phenotype, suppressible by Ras85DV12.UAS/Scer\GAL4twi.2PE

      (Lee et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ras85DV12.Scer\UAS; Scer\GAL4twi.2PE substantially suppresses the visceral mesoderm phenotype seen in stage 12 jeb-c1 homozygous embryos. Loss of visceral muscle founder cells in jeb-c1 mutant embryos, is suppressed by AlkScer\UAS.T:Hsap\NPM1; Scer\GAL4bap.3.

      (Lee et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      jeb-c1
      (Reim et al., 2012)
      jeb-c
      (Lee et al., 2003)
      jebc1
      (Vining et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)