FB2024_03 , released June 25, 2024
Allele: Dmel\prosV24
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General Information
Symbol
Dmel\prosV24
Species
D. melanogaster
Name
FlyBase ID
FBal0125203
Feature type
allele
Associated gene
Dmel\pros
Associated Insertion(s)
P{GawB-Δ24.G}prosV24
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Grosjean et al., 2001)
Progenitor genotype
prosV1
(Grosjean et al., 2001)
Associated Insertion(s)
P{GawB-Δ24.G}prosV24
Cytology
Description

Imprecise excision of the P{GawB} element. Scer\GAL4 sequences are still present. w sequences are not detected. A 2.9kb BamHI-PstI fragment ("pBSK") from the 3' end of the element appears to be intact. Surrounding genomic sequences are unaffected.

(Grosjean et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant larvae show a marked increase in the number of mitotically active cells in the brain compared to controls.

      (Colonques et al., 2011)

      The median lifespan for prosV24 animals (the age after egg laying at which 50% of homozygotes have died) is 5.48 days at 25oC.

      Homozygous third instar larvae show reduced locomotor activity compared to controls.

      Homozygous second instar larvae are indifferent to 0.1M sucrose in a taste response assay, in contrast to wild-type larvae which are significantly attracted by sucrose. They are repulsed by 0.3M NaCl (as are wild-type larvae).

      (Grosjean et al., 2003)

      The courtship index of heterozygous males towards decapitated Canton-S males is not significantly different from that of wild-type males towards decapitated Canton-S males. Homozygotes die mostly during pupal development.

      (Grosjean et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Voila24
      (Grosjean et al., 2001)
      prosV24
      (Grosjean et al., 2003)
      prosvoila24
      (Colonques et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)