FB2024_03 , released June 25, 2024
Allele: Dmel\RanG19V.Q69L.UAS
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General Information
Symbol
Dmel\RanG19V.Q69L.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0123740
Feature type
allele
Associated gene
Dmel\Ran
Associated Insertion(s)
Carried in Construct
P{UAS-Ran.G19V.Q69L}
Key Links
Transgenic product class
missense_variant
(Koizumi et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Koizumi et al., 2001)
Mutagen
in vitro construct
(Koizumi et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-Ran.G19V.Q69L}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of Ran (carries the amino acid replacements G19V and Q69L).

(Koizumi et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ran
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4nub.PK or Scer\GAL4elav.PLu die during the late first instar stage. First instar larvae show no abnormal behavioural phenotypes. No defects in axonal outgrowth or axon fascicle development are seen during embryogenesis. Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4h-1J3 die during the late second instar stage. First instar larvae show no abnormal behavioural phenotypes. No defects in axonal outgrowth or axon fascicle development are seen during embryogenesis. Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4pros.PMG die as pharate adults with no morphological defects. First instar larvae show no abnormal behavioural phenotypes. No defects in axonal outgrowth or axon fascicle development are seen during embryogenesis. Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4sev.EP.M show partial loss of photoreceptor cells (including loss of R7), resulting in a rough eye phenotype. Flies expressing ranG19V.Q69L.Scer\UAS under the control of Scer\GAL4GMR.PF show complete loss of photoreceptor, pigment and cone cells. The development of the interommatidial bristles appears unaffected.

      (Koizumi et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      RanG19V,Q69L
      (Cao et al., 2021)
      RanG19V.Q69L.Scer\UAS
      RanG19V.Q69L.UAS
      ranG19V.Q69L.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)