FlyBase Allele Report: Dmel\rpr[C.UAS]

General Information

Symbol

Dmel\rpr^C.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0123719

Feature type

allele

Associated gene

Dmel\rpr

Associated Insertion(s)

Carried in Construct

P{UAS-rpr.C.W}

Key Links

Transgenic product class

inframe_deletion

(Wing et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Wing et al., 1998)

Mutagen

in vitro construct

(Wing et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-rpr.C.W}

Cytology

Description

Amino acids 15-65 of rpr are driven by UAS sequences.

(Wing et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

rpr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^GMR.PF

(Wing et al., 2001)

viable, with Scer\GAL4^GMR.PF

(Wing et al., 1998)

visible, with Scer\GAL4^GMR.PF

(Wing et al., 2001)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Wing et al., 2001, Wing et al., 1998)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Wing et al., 1998)

ommatidium, with Scer\GAL4^GMR.PF

(Wing et al., 1998)

Detailed Description

Statement

Reference

When rpr^C.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF, flies are viable and exhibit a dosage sensitive elimination of eye tissue. Loss of ommatidia and disorganisation of mechanosensory bristles are also seen.

(Wing et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Gp150-52A, rpr^C.UAS has increased cell death phenotype, enhanceable by grim^UAS.cNa/Scer\GAL4^Gp150-52A

(Wing et al., 1998)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, rpr^C.UAS has increased cell death phenotype, suppressible | partially by Dronc^C318S.GMR

(Wing et al., 2001)

Scer\GAL4^GMR.PF, rpr^C.UAS has visible phenotype, suppressible | partially by Dronc^C318S.GMR

(Wing et al., 2001)

Scer\GAL4^GMR.PF, rpr^C.UAS has visible phenotype, suppressible | partially by Diap1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Wing et al., 2001)

Scer\GAL4^GMR.PF, rpr^C.UAS has increased cell death phenotype, suppressible | partially by Diap1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Wing et al., 2001)

Scer\GAL4^GMR.PF, rpr^C.UAS has increased cell death phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2001)

Scer\GAL4^GMR.PF, rpr^C.UAS has visible phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2001)

Enhancer of

Statement

Reference

Scer\GAL4^Gp150-52A/rpr^C.UAS is an enhancer of increased cell death phenotype of Scer\GAL4^Gp150-52A, grim^UAS.cNa

(Wing et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Gp150-52A, rpr^C.UAS has midline glial cell phenotype, enhanceable by grim^UAS.cNa/Scer\GAL4^Gp150-52A

(Wing et al., 1998)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, rpr^C.UAS has eye phenotype, suppressible | partially by Dronc^C318S.GMR

(Wing et al., 2001)

Scer\GAL4^GMR.PF, rpr^C.UAS has eye phenotype, suppressible | partially by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Wing et al., 2001)

Scer\GAL4^GMR.PF, rpr^C.UAS has eye phenotype, suppressible | partially by Diap1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Wing et al., 2001)

Scer\GAL4^GMR.PF, rpr^C.UAS has eye phenotype, suppressible | partially by Diap2^UAS.cWa, Scer\GAL4^GMR.PF

(Wing et al., 1998)

Enhancer of

Statement

Reference

Scer\GAL4^Gp150-52A/rpr^C.UAS is an enhancer of midline glial cell phenotype of Scer\GAL4^Gp150-52A, grim^UAS.cNa

(Wing et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

co-expression of rpr^C.Scer\UAS and grim^Scer\UAS.cNa leads to a loss of both midline glia and VUM neurons from all segments of the nerve cord. The addition of Iap2^Scer\UAS.cWa to rpr^C.Scer\UAS, Scer\GAL4^GMR.PF flies leads to a partial repression of the eye phenotype. 50% of males exhibit a wild-type eye, and 50% exhibit a milder roughened eye phenotype.

(Wing et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

rpr^C.Scer\UAS

rpr^C.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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