FB2024_03 , released June 25, 2024
Allele: Dmel\eIF4E1Scim-a
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General Information
Symbol
Dmel\eIF4E1Scim-a
Species
D. melanogaster
Name
Sensitized chromosome inheritance modifier a
FlyBase ID
FBal0122993
Feature type
allele
Associated gene
Dmel\eIF4E1
Associated Insertion(s)
P{SUPor-P}eIF4E1Scim-a
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Arquier et al., 2005)
Mutagen
Delta2-3 transposase
(Dobie et al., 2001)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}eIF4E1Scim-a
Cytology
Description

Insertion of P{SUPor-P} into intron 1 of eIF-4E, in tandem orientation. Insertion sites in eIF-4EScim-a and eIF-4EScim-b are identical.

(Dobie et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Developmental arrest at third larval instar.

      (Arquier et al., 2005)

      Dominantly decreases transmission of Dp(1;f)J21A to offspring to 13%. Recessive lethality acts at the third larval instar stage. Larval neuroblast squashes reveal an extremely low mitotic index. Interphase nuclei are two to four times the diameter of wild type nuclei. In rare nuclei the chromosome morphology is disrupted and the chromosomes appear hypocondensed.

      (Dobie et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Suppression of lethality of eIF-4EScim-a homozygotes allows emergence of viable (if a little small) adults. Weak rescue of eIF-4EScim-a/eIF-4E67Af by eIF-4ES251A.Scer\UAS is not improved by Lk6T424D.Scer\UAS.

      (Arquier et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      eIF-4EScim-a
      eIF4E1Scim-a
      Name Synonyms
      Sensitized chromosome inheritance modifier a
      (Dobie et al., 2001)
      Secondary FlyBase IDs
        References (2)