FB2024_03 , released June 25, 2024
Allele: Dmel\Su(H)RC-9Xm
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General Information
Symbol
Dmel\Su(H)RC-9Xm
Species
D. melanogaster
Name
FlyBase ID
FBal0120610
Feature type
allele
Associated gene
Dmel\Su(H)
Associated Insertion(s)
Carried in Construct
P{Su(H)RC-9Xm}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Barolo et al., 2000)
Progenitor genotype
Su(H)+t6.0
(Barolo et al., 2000)
Carried in construct
P{Su(H)RC-9Xm}
Cytology
Description

Construct: Nucleotide substitution: mutation of all nine Su(H) protein binding sites within the Autoregulatory Socket Enhancer (ASE) sequences downstream of the Su(H) gene.

(Barolo et al., 2000)
Allele components
Component
Use(s)
Encoded product / tool
Su(H)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying 1 copy of Su(H)RC-9Xm show bristle shaft-to-socket transformations.

      (Barolo et al., 2002)

      The mean transepithelial potential (TEP) and mechanoreceptor potential (MRP) of mechanosensory bristles of flies carrying Su(H)RC-9Xm in a Su(H)unspecified background are reduced compared to wild type. The mechanoreceptor current (MRC) is also reduced compared to wild type. A clearly identifiable tormogen cell is evident in the mutant bristles. Flies carrying two copies of Su(H)RC-9Xm in a wild-type background show double-socket bristles. The phenotype is mitigated by reducing the dosage of the transgene.

      (Barolo et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Su(H)RC-9Xm has visible phenotype, enhanceable by groE73/gro[+]

      (Barolo et al., 2002)

      Su(H)RC-9Xm has visible phenotype, enhanceable by CtBP[+]/CtBP87De-10

      (Barolo et al., 2002)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Su(H)RC-9Xm has macrochaeta phenotype, enhanceable by groE73/gro[+]

      (Barolo et al., 2002)

      Su(H)RC-9Xm has macrochaeta phenotype, enhanceable by CtBP[+]/CtBP87De-10

      (Barolo et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Su(H)RC-9Xm rescues Su(H)unspecified

      (Barolo et al., 2000)
      Comments

      Su(H)unspecified flies carrying one copy of Su(H)RC-9Xm are viable and fertile and more than 99.5% of macrochaetae are wild type. A low frequency of double shafts and missing bristles (less than 0.5% combined) is seen.

      (Barolo et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Su(H)RC-9Xm
      Su(H)RC9Xm
      (Barolo et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)