FlyBase Allele Report: Dmel\wdb[EP3559]

General Information

Symbol

Dmel\wdb^EP3559

Species

D. melanogaster

Name

FlyBase ID

FBal0119629

Feature type

allele

Associated gene

Dmel\wdb

Associated Insertion(s)

P{EP}EP3559

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Hannus et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}EP3559

Cytology

Description

The orientation of the P{EP} element is the same as the direction of wdb transcription.

(Shulman and Feany, 2003)

The P{EP} element is inserted within the 5' UTR.

(Kraut et al., 2001)

P{EP} insertion.

(Abdelilah-Seyfried et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:27,582,191..27,582,191 [-]

(Vereshchagina et al., 2008, Sathyanarayanan et al., 2004, Shulman and Feany, 2003, Hannus et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor rhythm, with Scer\GAL4^tim.PE

(Sathyanarayanan et al., 2004)

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

visible, with Scer\GAL4^GMR.PF

(Müller et al., 2005, Shulman and Feany, 2003)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

eye, with Scer\GAL4^GMR.PF

(Vereshchagina et al., 2008, Müller et al., 2005, Shulman and Feany, 2003)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

tormogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

tormogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

wing hair | increased number, with Scer\GAL4^ap-md544

(Hannus et al., 2002)

Detailed Description

Statement

Reference

Expression of wdb^EP3559 in the eye under the control of Scer\GAL4^GMR.PF results in very mild defects in ommatidial organisation.

(Vereshchagina et al., 2008)

Expression of wdb^EP3559 under the control of Scer\GAL4^GMR.PF results in a big eye phenotype.

(Müller et al., 2005)

Expression of wdb^EP3559 under the control of Scer\GAL4^tim.PE lengthens the period of locomotor activity rhythms; the period is about 0.7 hours longer than that of controls. The lengthening of the period is dose-dependent; the period is increased by 1.5-2 hours if the temperature is increased to 29^oC or two copies of wdb^EP3559 are present. 5% of the flies are arrhythmic after about 4 days in constant darkness conditions.

(Sathyanarayanan et al., 2004)

Expression of wdb^EP3559 under the control of Scer\GAL4^GMR.PF results in a very mild rough eye phenotype.

(Shulman and Feany, 2003)

Expression of wdb^EP3559 under the control of Scer\GAL4^ap-md544 results in many cells forming multiple wing hairs; an average of 49+/-20 cells in the fifth wing cell have a multiple wing hair phenotype.

(Hannus et al., 2002)

Mutant larvae expressing wdb^EP3559 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses. Mutant larvae expressing wdb^EP3559 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects.

(Kraut et al., 2001)

Expression of wdb^EP3559 under the control of Scer\GAL4^sca-537.4 results in sensory organs with two sockets and two shafts, two sockets and one shaft, one socket and two shafts and dot-like socket morphology.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, wdb^EP3559 has visible phenotype, non-enhanceable by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, wdb^EP3559 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, wdb^EP3559 has visible phenotype, non-suppressible by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, wdb^EP3559 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

wdb^EP3559/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, foxo^GS9928

(Vereshchagina et al., 2008)

wdb^EP3559, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Enhancer of

Statement

Reference

wdb^EP3559, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

wdb^EP3559, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

NOT Suppressor of

Statement

Reference

wdb^EP3559, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ap-md544, wdb^EP3559 has wing hair | increased number phenotype, suppressible by mts^XE-2202

(Hannus et al., 2002)

Scer\GAL4^ap-md544, wdb^EP3559 has wing hair | increased number phenotype, suppressible by mts^XE-2258

(Hannus et al., 2002)

Enhancer of

Statement

Reference

wdb^EP3559/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, foxo^GS9928

(Vereshchagina et al., 2008)

wdb^EP3559, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

wdb^EP3559, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Enhancer of

Statement

Reference

wdb^EP3559, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

wdb^EP3559/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

wdb^EP3559/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Suppressor of

Statement

Reference

wdb^EP3559, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

NOT Suppressor of

Statement

Reference

wdb^EP3559, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

wdb^EP3559/Scer\GAL4^sca-537.4 is a non-suppressor of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of wdb^EP3559 in animals expressing foxo^GS9928 under the control of Scer\GAL4^GMR.PF enhances the eye phenotype.

(Vereshchagina et al., 2008)

Expression of one copy of wdb^EP3559 under the control of Scer\GAL4^tim.PE in a dco^L background lengthens the period of locomotor activity rhythms from 24.7 to 26 hours. Expression of one copy of wdb^EP3559 under the control of Scer\GAL4^tim.PE in a dco^g background lengthens the period of locomotor activity rhythms from 27.6 to 30.3 hours.

(Sathyanarayanan et al., 2004)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by wdb^EP3559.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

53712

w^*; P{neoFRT}82B P{EP}EP3559 wdb¹⁴/TM6B, Tb¹

53713

w^*; P{neoFRT}82B P{EP}EP3559 wdb¹²/TM6B, Tb¹

Notes on Origin

Discoverer

Comments

Precise excision of the P{EP} element reverts the modifying effect of wdb^EP3559 on the rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Shulman and Feany, 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

BcDNA:LD34343^EP3559

(Kraut et al., 2001, Kraut et al., 2001)

EP(3)3559

(Abdelilah-Seyfried et al., 2000)

EP3559^EP3559

wdb^EP3559

(Bandyopadhyay et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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