FlyBase Allele Report: Dmel\slmb[8]

General Information

Symbol

Dmel\slmb⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0117354

Feature type

allele

Associated gene

Dmel\slmb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Miletich and Limbourg-Bouchon, 2000)

Mutagen

P-element activity

(Miletich and Limbourg-Bouchon, 2000)

Progenitor genotype

slmb^P245

(Miletich and Limbourg-Bouchon, 2000)

Cytology

Description

The original P{lacW}slmb^P245 insertion, and several kb of genomic DNA has been removed, including a large part of the 3' UTR as well as the first exon of slmb.

(Miletich and Limbourg-Bouchon, 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm, with slmb^L.hs

(Grima et al., 2002)

abnormal locomotor rhythm, with slmb^L.hs

(Grima et al., 2002)

abnormal neuroanatomy | pupal stage | somatic clone

(Wong et al., 2013)

lethal - all die before end of larval stage (with Df(3R)e-R1)

(Miletich and Limbourg-Bouchon, 2000)

lethal - all die before end of larval stage (with slmb⁴¹)

(Miletich and Limbourg-Bouchon, 2000)

lethal - all die before end of larval stage | recessive

(Miletich and Limbourg-Bouchon, 2000)

lethal - all die during first instar larval stage, with slmb^L.hs

(Heriche et al., 2003)

lethal - all die during third instar larval stage | heat sensitive, with slmb^L.hs

(Heriche et al., 2003)

neoplasia | somatic clone

(Skwarek et al., 2014)

some die during larval stage (with Df(3R)e-R1)

(Miletich and Limbourg-Bouchon, 2000)

some die during larval stage (with slmb⁴¹)

(Miletich and Limbourg-Bouchon, 2000)

some die during larval stage | recessive

(Miletich and Limbourg-Bouchon, 2000)

Phenotype Manifest In

egg chamber (with slmb^9H4-17), with slmb^L.hs

(Morais-de-Sá et al., 2014)

larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone

(Wong et al., 2013)

wing disc | somatic clone

(Skwarek et al., 2014)

Detailed Description

Statement

Reference

slmb^L.hs; slmb⁸/slmb^9H4-17 transheterozygous ovaries exhibit defects in stau localisation and in the organisation of epithelial follicle cells. Mutant egg chambers exhibit multiple cell layers.

(Morais-de-Sá et al., 2014)

Neoplastic transformation is seen in slmb⁸ mutant wing disc clones.

(Skwarek et al., 2014)

slmb⁸ mutant ddaC neuron clones exhibit dendrite pruning defects at 16 hours after puparium formation. No difference is seen at the white prepupal stage.

(Wong et al., 2013)

slmb⁸, slmb^L.hs mutants, in the absence of heat shock, exhibit early lethality. A single 30 minute heat shock at 37[o]C during first instar is enough to allow some larvae to reach the wandering third instar stage 4 days later. These larval display small imaginal discs.

(Heriche et al., 2003)

When slmb^L.hs is used to rescue slmb⁸ mutants to adulthood, mutant adults completely arrhythmic in constant dark (DD) conditions. Ventral lateral neurons are normal. These animals do not display the light-off anticipation of activity that characterises a functional clock. The addition of slmb^Scer\UAS.cGa driven by Scer\GAL4^P2.4.Pdf or Scer\GAL4¹¹¹⁸ rescues these phenotype.

(Grima et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

slmb⁸ has abnormal neuroanatomy | pupal stage | somatic clone phenotype, enhanceable by Mical¹⁵²⁵⁶

(Wong et al., 2013)

Enhancer of

Statement

Reference

slmb⁸ is an enhancer of visible | adult stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

slmb⁸ is an enhancer of abnormal neuroanatomy | pupal stage | somatic clone phenotype of Mical¹⁵²⁵⁶

(Wong et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

slmb⁸ has larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone phenotype, enhanceable by Mical¹⁵²⁵⁶

(Wong et al., 2013)

Suppressed by

Statement

Reference

slmb^9H4-17/slmb⁸, slmb^L.hs has egg chamber phenotype, suppressible | partially by aPKC^k06403/aPKC[+]

(Morais-de-Sá et al., 2014)

Enhancer of

Statement

Reference

slmb⁸ is an enhancer of wing | adult stage phenotype of Mmus\Bax^UAS.cGa, Scer\GAL4^vg.PM

(Colin et al., 2014)

slmb⁸ is an enhancer of larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone phenotype of Mical¹⁵²⁵⁶

(Wong et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Lowering aPKC levels, by a aPKC^k06403 heterozygous background, partially suppresses the multilayering cell phenotype found in slmb^L.hs;slmb⁸/slmb^9H4-17 mutants.

(Morais-de-Sá et al., 2014)

Mical¹⁵²⁵⁶ slmb⁸ double mutant ddaC neuron clones have more severe dendrite pruning defects at 16 hours after puparium formation as are seen in either single mutant alone. No change is seen in the level of pruning at the white prepupal stage.

(Wong et al., 2013)

Xenogenetic Interactions

Statement

Reference

The presence of slmb⁸ enhances the notched wing phenotype observed in flies expressing Mmus\Bax^Scer\UAS.cGa under the control of Scer\GAL4^vg.PM.

(Colin et al., 2014)

Complementation and Rescue Data

Rescued by

slmb⁸ is rescued by slmb^L.hs

(Grima et al., 2002)

slmb⁸/slmb^L.hs is rescued by slmb^UAS.cGa/Scer\GAL4¹¹¹⁸

(Grima et al., 2002)

slmb⁸/slmb^L.hs is rescued by slmb^UAS.cGa/Scer\GAL4^P2.4.Pdf

(Grima et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

slmb⁸

(Colin et al., 2014, Morais-de-Sá et al., 2014, Skwarek et al., 2014, Morais-de-Sá et al., 2013, Wong et al., 2013, Grima et al., 2012, Heriche et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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