FlyBase Allele Report: Dmel\trio[S138606]

General Information

Symbol

Dmel\trio^S138606

Species

D. melanogaster

Name

FlyBase ID

FBal0117280

Feature type

allele

Associated gene

Dmel\trio

Associated Insertion(s)

P{lacW}trio^S138606

Carried in Construct

Also Known As

trio^P3, l(3)s138606

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Newsome et al., 2000)

Mutagen

Delta2-3 transposase

(Deak et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}trio^S138606

Cytology

Description

P{lacW} in the first exon of the trio transcript, in the untranslated region. P{lacW}trio^S137203 and P{lacW}trio^S138606 map within 5bp of each other.

(Bateman et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:1,034,861..1,034,861 [-]

(Bateman et al., 2000, Newsome et al., 2000, Deak et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die | recessive

(Bateman et al., 2000)

visible | recessive

(Bateman et al., 2000)

Phenotype Manifest In

larval abdominal segmental nerve

(Bateman et al., 2000)

larval intersegmental nerve

(Bateman et al., 2000)

larval longitudinal connective

(Bateman et al., 2000)

photoreceptor cell & axon (with trio¹)

(Newsome et al., 2000)

photoreceptor cell & axon (with trio⁸)

(Newsome et al., 2000)

wing

(Bateman et al., 2000)

Detailed Description

Statement

Reference

Adult escapers have a wing posture phenotype. Mutants show a short stop phenotype, with defects in the ability of nerve branches to reach target muscles. ISNb (where the effect is most pronounced) and SNa are most sensitive to the loss of trio activity. In addition, there are occasional defects in epidermal muscle attachment sites. The CNS also shows pathfinding errors resulting in breaks in the longitudinal connectives. The axons often fail to traverse the segment boundary.

(Bateman et al., 2000)

Less than 10% of trio^S138606/trio¹ and trio^S138606/trio⁸ animals show defects in photoreceptor axon projection, having a "medulla bypass" phenotype.

(Newsome et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

trio^S138606/trio¹ has phenotype, enhanceable by Pak[+]/Pak¹⁶

(Newsome et al., 2000)

trio^S138606/trio¹ has photoreceptor cell & axon phenotype, enhanceable by Pak[+]/Pak¹⁶

(Newsome et al., 2000)

trio^S138606/trio¹ has phenotype, enhanceable by Pak[+]/Pak²⁰

(Newsome et al., 2000)

trio^S138606/trio¹ has photoreceptor cell & axon phenotype, enhanceable by Pak[+]/Pak²⁰

(Newsome et al., 2000)

trio^S138606/trio⁸ has phenotype, enhanceable by Pak[+]/Pak¹⁶

(Newsome et al., 2000)

trio^S138606/trio⁸ has photoreceptor cell & axon phenotype, enhanceable by Pak[+]/Pak¹⁶

(Newsome et al., 2000)

trio^S138606/trio⁸ has phenotype, enhanceable by Pak[+]/Pak²⁰

(Newsome et al., 2000)

trio^S138606/trio⁸ has photoreceptor cell & axon phenotype, enhanceable by Pak[+]/Pak²⁰

(Newsome et al., 2000)

Enhancer of

Statement

Reference

trio^S138606/trio[+] is an enhancer of phenotype of Lar^13.2

(Bateman et al., 2000)

trio^S138606/trio[+] is an enhancer of larval intersegmental nerve phenotype of Lar^13.2

(Bateman et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of trio^S138606/trio¹ or trio^S138606/trio⁸ animals showing defects in photoreceptor axon projection (having a "medulla bypass" phenotype) is enhanced if they are also heterozygous for either Pak¹⁶ or Pak²⁰.

(Newsome et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

trio^S138606/Df(3L)Ar12-1 is partially rescued by Scer\GAL4^T155/trio^UAS.cBa

(Bateman et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

1386/06

(Deak et al., 1997)

l(3)S138606

(Saito et al., 2002)

l(3)s138606

(Newsome et al., 2000)

trio^P3

(Albin and Davis, 2004, Newsome et al., 2000)

trio^S138606

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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