FB2024_03 , released June 25, 2024
Allele: Dmel\RyRQ3878X
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General Information
Symbol
Dmel\RyRQ3878X
Species
D. melanogaster
Name
FlyBase ID
FBal0104573
Feature type
allele
Associated gene
Dmel\RyR
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Dockendorff et al., 2000)
Progenitor genotype
Cytology
Description

Coordinates for nucleotide substitution are with respect to RyR transcript variant D (NM_057646.2) and coordinates for amino acid replacements are with respect to RyR isoform D (NP_476994.1).

(Gao et al., 2013)

Nucleotide substitution: C11786T.

(Gao et al., 2013)

Amino acid replacement: Q3878term.

(Gao et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,883,625..8,883,625 [+]
Nucleotide change:

C8883625T

Reported nucleotide change:

C11786T

Amino acid change:

Q3892term | RyR-PA; Q3878term | RyR-PB; Q3892term | RyR-PC; Q3878term | RyR-PD; Q3882term | RyR-PE; Q3884term | RyR-PF; Q3888term | RyR-PG; Q3895term | RyR-PH; Q3891term | RyR-PI; Q3880term | RyR-PJ

Reported amino acid change:

Q3878term

Comment:

Reported coordinates are relative to isoform RyR-RD.

(Gao et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes show resistance to halothane compared to wild type.

      RP2 neurons in heterozygous larvae respond to 5mM caffeine more weakly than wild-type RP2 neurons.

      (Gao et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      RyRQ3878X/RyR[+] is a non-enhancer of partially lethal - majority die phenotype of Scer\GAL4elav-C155, cacRQ,SL.UAS.EGFP

      (Brusich et al., 2018)
      NOT Suppressor of
      Statement
      Reference

      RyRQ3878X/RyR[+] is a non-suppressor of partially lethal - majority die phenotype of Scer\GAL4elav-C155, cacRQ,SL.UAS.EGFP

      (Brusich et al., 2018)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      RyRΔ25

      (Gao et al., 2013)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      RyRQ3878X
      (Brusich et al., 2018, Kahsai and Cook, 2018, Lam et al., 2018)
      dRyrQ3878X
      (Gao et al., 2013)
      l(2)44Fa3
      (Gao et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)