FB2024_03 , released June 25, 2024
Allele: Dmel\l(3)cl-R31
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General Information
Symbol
Dmel\l(3)cl-R31
Species
D. melanogaster
Name
FlyBase ID
FBal0104493
Feature type
allele
Associated gene
l(3)cl-R3
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Newsome et al., 2000)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When scrib1 clones are made in regions of eye disc tissue that are l(3)cl-R31 (made by FLP clones in the eye), the scrib1 clone is not eliminated by apoptosis as seen in wild-type tissue but overproliferates, losing recognisable structure, resulting in lethality.

      (Brumby and Richardson, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Induced on: a P{neoFRT}82B w+ chromosome. Selected as: a presumed recessive cell lethal mutation on the P{neoFRT}82B w+ chromosome that enhances the size of w- Scer\FLP1ey.PN induced clones in the eye (because cells homozygous for the P{neoFRT}82B w+ chromosome carrying the putative cell lethal do not survive), but does not have deleterious effects on viability and fertility.

      (Newsome et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      3R cl
      (Chou et al., 2010)
      3R3.7
      (Meyer et al., 2008)
      cl3R3
      (Newsome et al., 2000)
      l(3)cl-R31
      (Chou et al., 2010, Meyer et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)