FlyBase Allele Report: Dmel\Src42A[Jp45]

General Information

Symbol

Dmel\Src42A^Jp45

Species

D. melanogaster

Name

FlyBase ID

FBal0103955

Feature type

allele

Associated gene

Dmel\Src42A

Associated Insertion(s)

P{}Src42A^Jp45

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Tateno et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{}Src42A^Jp45

Cytology

Description

P-element insertion in the 5' untranslated region of Src42A at approximately base 40.

(Tateno et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:5,982,060..5,982,069

(Tateno et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Tateno et al., 2000)

Phenotype Manifest In

adult thorax | dorsal

(Tateno et al., 2000)

mesothoracic bristle

(Tateno et al., 2000)

scutum

(Tateno et al., 2000)

Detailed Description

Statement

Reference

2.8 +/- 0.3% of homozygotes survive to adulthood. Escapers have a cleft in the dorsal midline of the thorax. The phenotype varies in severity from nearly normal, through a midline devoid of bristles to a cleft notum.

(Tateno et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Src42A^Jp45 has lethal | recessive phenotype, enhanceable by hep[+]/hep^r75

(Tateno et al., 2000)

Src42A^Jp45 has lethal | recessive phenotype, enhanceable by bsk²/bsk[+]

(Tateno et al., 2000)

Src42A^Jp45 has lethal | recessive phenotype, enhanceable by Btk^k05610/Btk^k00206

(Tateno et al., 2000)

Suppressed by

Statement

Reference

Src42A^Jp45 has lethal | recessive phenotype, suppressible by puc^E69/puc[+]

(Tateno et al., 2000)

Other

Statement

Reference

Src42A^Jp45/Src42A[+], p130CAS¹ has partially lethal - majority die | embryonic stage phenotype

(Tikhmyanova et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Src42A^Jp45 has adult thorax | dorsal phenotype, enhanceable by hep[+]/hep^r75

(Tateno et al., 2000)

Suppressed by

Statement

Reference

Src42A^Jp45 has adult thorax | dorsal phenotype, suppressible by puc^E69/puc[+]

(Tateno et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

p130CAS¹ homozygous mutants in combination with either Fak56D^CG1 heterozygous or homozygous mutants yield no viable adult offspring. The Fak56D^CG1/Fak56D^CG1; p130CAS¹/+ genotype significantly reduces the viability of adults. Analysis of the double homozygous mutant lethal phenotype indicates that most (95%) of the embryos do not hatch. The few escapers survive to pupal stages, but do not emerge.

In contrast to either Fak56D^CG1 or p130CAS¹ homozygotes, onnly 5% of double mutants produce cuticles and almost all observed cuticles are marked by dorsal and/or ventral holes, indicating dorsal closure defects. Additionally, double mutant cuticles exhibit fused or missing denticle belts, a phenotype never observed in Fak56D^CG1 homozygotes alone.

Approximately 29% of Src42A^Jp45/+; p130CAS¹/p130CAS¹ double mutants emerge as adults.

(Tikhmyanova et al., 2010)

The lethality of homozygotes is dominantly enhanced by hep^r75 or bsk² and dominantly suppressed by puc^E69. The severity of the dorsal cleft phenotype is dominantly enhanced by hep^r75 and dominantly suppressed by puc^E69. Btk29A^k00206/Btk29A^k05610 enhances the lethality of Src42A^Jp45.

(Tateno et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

109635

w^*; P{lacW}Src42A^Jp45 / SM1

Notes on Origin

Discoverer

Comments

Excision of the P-element reverts the semi-lethality and cleft thorax phenotype.

(Tateno et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Jp45

(Tateno et al., 2000)

Src42A^JP45

(Tikhmyanova et al., 2010)

Src42A^Jp45

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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