FlyBase Allele Report: Dmel\Rca1[33X16]

General Information

Symbol

Dmel\Rca1^33X16

Species

D. melanogaster

Name

FlyBase ID

FBal0102862

Feature type

allele

Associated gene

Dmel\Rca1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lear et al., 1999)

Mutagen

P-element activity

(Lear et al., 1999)

Progenitor genotype

Rca1⁰³³⁰⁰

(Lear et al., 1999)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ganglion mother cell GMC1-1a

(Lear et al., 1999)

ganglion mother cell GMC4-2a

(Lear et al., 1999)

larval EL neuron

(Lear et al., 1999)

Detailed Description

Statement

Reference

In mutant embryos, the ganglion mother cells, GMC1-1a and GMC4-2a fail to divide into their normal progeny and appear to adopt aCC and RP2 neuron fates respectively. An approximately 10% loss of EL neurons is also seen.

(Lear et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

N^int.hs, Rca1^33X16 has ganglion mother cell GMC4-2a phenotype

(Lear et al., 1999)

N^int.hs, Rca1^33X16 has ganglion mother cell GMC1-1a phenotype

(Lear et al., 1999)

Rca1^33X16, numb² has ganglion mother cell GMC4-2a phenotype

(Lear et al., 1999)

Rca1^33X16, numb² has ganglion mother cell GMC1-1a phenotype

(Lear et al., 1999)

Rca1^33X16, numb² has ganglion mother cell phenotype

(Lear et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

In Rca1^33X16, numb² double mutants the GMC4-2a ganglion mother cell fails to divide and adopts the RP2sib neuron fate in about 1 in 2 cases. In Rca1^33X16, numb² double mutants the GMC1-1a ganglion mother cell fails to divide and adopts the pCC neuron fate in about 3/4 of cases. In Rca1^33X16, numb² double mutants the ganglion mother cell that normally mothers the U/CQ and U/CQ sibling neurons fails to divide and often adopts the U/CQ sibling neuron fate.

(Lear et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Created by imprecise excision of the P-element in Rca1⁰³³⁰⁰.

(Lear et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rca1^33X16

rca1^33X16

(Lear et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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