FB2024_03 , released June 25, 2024
Allele: Dmel\Ptp69Dunspecified
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General Information
Symbol
Dmel\Ptp69Dunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0098312
Feature type
allele
Associated gene
Dmel\Ptp69D
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        glial cell & lamina

        (Garrity et al., 1999)

        lamina plexus

        (Garrity et al., 1999)

        medulla

        (Garrity et al., 1999)

        photoreceptor cell R1 & axon

        (Garrity et al., 1999)

        photoreceptor cell R2 & axon

        (Garrity et al., 1999)

        photoreceptor cell R3 & axon

        (Garrity et al., 1999)

        photoreceptor cell R4 & axon

        (Garrity et al., 1999)

        photoreceptor cell R5 & axon

        (Garrity et al., 1999)

        photoreceptor cell R6 & axon

        (Garrity et al., 1999)
        Detailed Description
        Statement
        Reference

        In Ptp69Dunspecified mutants, R cell axons form a largely normal topographic array in both the lamina and medulla. However the lamina plexus is wavy, of varying thickness, and discontinuous. In contrast to wild type, thicker than normal bundles of axon extend into the medulla. These features suggest that in Ptp69Dunspecified mutants, many R1-R6 axons fail to stop in the lamina and terminate in the medulla. Many of these axons remain within the medulla in the adult. In Ptp69Dunspecified mutants LPC (lamina precursor cell) proliferation and lamina neuron differentiation were normal. The organisation of lamina neurons was also largely normal. Glia migrate into the lamina as in wild type but form irregular rows.

        (Garrity et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Other
        Statement
        Reference

        Ptp10D1, Ptp69Dunspecified has larval VL3/4 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D1, Ptp69Dunspecified has larval RP2 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101/Ptp10D1, Ptp69Dunspecified has larval VL3/4 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101/Ptp10D1, Ptp69Dunspecified has larval RP2 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101/Ptp10D1, Ptp69Dunspecified has larval intersegmental nerve phenotype

        (Sun et al., 2000)

        Ptp10D101/Ptp10D1, Ptp69Dunspecified has presumptive embryonic/larval central nervous system phenotype

        (Sun et al., 2000)

        Ptp10D1, Ptp69Dunspecified has larval intersegmental nerve phenotype

        (Sun et al., 2000)

        Ptp10D101/Ptp10D1, Ptp69Dunspecified has larval VO2 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101/Ptp10D1, Ptp69Dunspecified has larval VO1 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101/Ptp10D1, Ptp69Dunspecified has larval abdominal segmental nerve phenotype

        (Sun et al., 2000)

        Ptp10D101/Ptp10D1, Ptp69Dunspecified has larval RP5 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)101, Ptp69Dunspecified has larval VL3/4 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)101, Ptp69Dunspecified has larval RP2 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)101, Ptp69Dunspecified has larval intersegmental nerve phenotype

        (Sun et al., 2000)

        Df(1)101, Ptp69Dunspecified has presumptive embryonic/larval central nervous system phenotype

        (Sun et al., 2000)

        Df(1)101, Ptp69Dunspecified has larval VO2 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)101, Ptp69Dunspecified has larval VO1 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D1, Ptp69Dunspecified has presumptive embryonic/larval central nervous system phenotype

        (Sun et al., 2000)

        Df(1)101, Ptp69Dunspecified has larval abdominal segmental nerve phenotype

        (Sun et al., 2000)

        Df(1)101, Ptp69Dunspecified has larval RP5 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)Δ59, Ptp69Dunspecified has larval VL3/4 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)Δ59, Ptp69Dunspecified has larval RP2 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)Δ59, Ptp69Dunspecified has larval intersegmental nerve phenotype

        (Sun et al., 2000)

        Df(1)Δ59, Ptp69Dunspecified has presumptive embryonic/larval central nervous system phenotype

        (Sun et al., 2000)

        Df(1)Δ59, Ptp69Dunspecified has larval VO2 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)Δ59, Ptp69Dunspecified has larval VO1 motor neuron phenotype

        (Sun et al., 2000)

        Df(1)Δ59, Ptp69Dunspecified has larval abdominal segmental nerve phenotype

        (Sun et al., 2000)

        Df(1)Δ59, Ptp69Dunspecified has larval RP5 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D1, Ptp69Dunspecified has larval VO2 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101, Ptp69Dunspecified has larval VL3/4 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101, Ptp69Dunspecified has larval RP2 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101, Ptp69Dunspecified has larval intersegmental nerve phenotype

        (Sun et al., 2000)

        Ptp10D101, Ptp69Dunspecified has presumptive embryonic/larval central nervous system phenotype

        (Sun et al., 2000)

        Ptp10D101, Ptp69Dunspecified has larval VO2 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101, Ptp69Dunspecified has larval VO1 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D101, Ptp69Dunspecified has larval abdominal segmental nerve phenotype

        (Sun et al., 2000)

        Ptp10D101, Ptp69Dunspecified has larval RP5 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D1, Ptp69Dunspecified has larval VO1 motor neuron phenotype

        (Sun et al., 2000)

        Ptp10D1, Ptp69Dunspecified has larval abdominal segmental nerve phenotype

        (Sun et al., 2000)

        Ptp10D1, Ptp69Dunspecified has larval RP5 motor neuron phenotype

        (Sun et al., 2000)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        When RhoGAP93BdsRNA.Scer\UAS is driven by Scer\GAL4elav.PLu in a Ptp69Dunspecified/Ptp10Dunspecified background no midline crossing defects are seen.

        (Hu, 2005)

        Ptp69Dunspecified in double mutant combination with either Ptp10D1, Ptp10D1/Ptp10D101, Df(1)101 or Df(1)Δ59 results in alterations in many central nervous system axonal pathways in the embryo. The contralaterally projecting interneuronal axons of the NB 2-5 lineage cross the midline and turn anteriorly in a normal manner, but then double back across the midline after about two segments and grow posteriorly in the ipsilateral longitudinal tract. The axons of the ipsilateral intersegmental neurons grow anteriorly for a short distance and stop. The ISNd motorneuron extends an axon toward the midline that stalls and never enters the ISN root. In the NB 4-2 lineage, the RP2 axons stall before reaching their target, and the CoR axons do not branch onto all of their target muscles. The projection of local interneurons across the midline in the anterior commissure appears wild type, except that the axons always defasciculate into two bundles after crossing the midline. Ectopic interneuronal projections form on the ipsilateral side, and project across segmental boundaries in the anterior direction (these axons never form in wild type). In the NB 3-1 lineage, the RP neurons (RP1, RP3, RP4 and RP5) extend axons normally across the commissure and into the ISNb nerve, although they do not form normal synapses. The interneuronal projections are radically altered; they still cross the midline, but do not form defined anterior and posterior projections in the contralateral connective. Instead, they grow anteriorly in a circular path around the neuropil, contacting the midline at the end of their trajectory. No alterations in the numbers or positions of cell bodies of the progeny of NBs 3-1, 4-2 or 2-5 are seen in these embryos.

        (Sun et al., 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Ptp69Dunspecified is rescued by Ptp69D+t10.5

        (Desai et al., 1996)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Ptp69Dunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (4)