FB2024_03 , released June 25, 2024
Allele: Dmel\NFLNΔ10-12.UAS
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General Information
Symbol
Dmel\NFLNΔ10-12.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0097214
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
P{UAS-N.FLNΔ10-12}
Also Known As
FLNΔ10-12
Key Links
Transgenic product class
inframe_deletion
(Zecchini et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Zecchini et al., 1999)
Mutagen
in vitro construct
(Zecchini et al., 1999)
Progenitor genotype
NFLN.UAS
(Zecchini et al., 1999)
Carried in construct
P{UAS-N.FLNΔ10-12}
Cytology
Description

Deletion of amino acids 412-566, inclusive, which encode EGF repeats 10-13 (repeats 11 and 12 contain the Dl binding sites). EGF repeats 9 and 14 are fused.

(Zecchini et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
N
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When expression is driven by Scer\GAL4da.G32 in a wild type background, the resulting phenotype resembles that of puc1 mutants.

      (Zecchini et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      NFLNΔ10-12.UAS/Scer\GAL4da.G32 partially rescues Nunspecified

      (Zecchini et al., 1999)
      Fails to rescue

      Scer\GAL415J2/NFLNΔ10-12.UAS fails to rescue Nl1N-ts1

      (Kuzina et al., 2011)
      Comments

      Expression of NFLNΔ10-12.Scer\UAS under the control of Scer\GAL415J2 fails to rescue the Nl1N-ts1 axon phenotype.

      (Kuzina et al., 2011)

      Partially rescues the neurogenic phenotype of N mutants, with rescue only evident on the dorsal surface.

      (Zecchini et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      NFLNΔ10-12.Scer\UAS
      NFLNΔ10-12.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (6)