FB2024_03 , released June 25, 2024
Allele: Dmel\NFLN.ΔBRV.UAS
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General Information
Symbol
Dmel\NFLN.ΔBRV.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0097213
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
P{UAS-N.FLNΔBRV}
Also Known As
FLNΔBRV
Key Links
Transgenic product class
inframe_deletion
(Zecchini et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Zecchini et al., 1999)
Mutagen
in vitro construct
(Zecchini et al., 1999)
Progenitor genotype
NΔBam.RV.hs
(Zecchini et al., 1999)
Carried in construct
P{UAS-N.FLNΔBRV}
Cytology
Description

Coding region for N is deleted for BRV domain (carboxy-terminal to the Cdc10/ANK repeats), and is expressed from UAS regulatory sequences.

(Zecchini et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
N
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When expression is driven by Scer\GAL4da.G32, embryos show no effect on the ventral epidermis but generated a hole in the dorsal epidermis similar to that caused by hep and bsk mutants. When expression is driven by Scer\GAL4pnr-MD237 the phenotype of the embryos is indistinguishable from that of hep or bsk mutants.

      (Zecchini et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4da.G32/NFLN.ΔBRV.UAS partially rescues Nunspecified

      (Zecchini et al., 1999)
      Comments

      Rescues the dorsal mutant phenotype of N embryos effectively and the ventral mutant phenotype to a lesser extent. Rescues the dorsal closure defect significantly.

      (Zecchini et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      NFLN.ΔBRV.Scer\UAS
      NFLN.ΔBRV.UAS
      NFLN.ΔBRV
      Name Synonyms
      Secondary FlyBase IDs
        References (2)