FB2024_03 , released June 25, 2024
Allele: Dmel\sv6
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General Information
Symbol
Dmel\sv6
Species
D. melanogaster
Name
FlyBase ID
FBal0096665
Feature type
allele
Associated gene
Dmel\sv
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Kavaler et al., 1999)
Mutagen
ethyl methanesulfonate
(Kavaler et al., 1999)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      anterior dorsocentral bristle & tormogen cell

      (Kavaler et al., 1999)

      anterior dorsocentral bristle & trichogen cell

      (Kavaler et al., 1999)

      eye

      (Kavaler et al., 1999)

      lens

      (Kavaler et al., 1999)

      macrochaeta

      (Kavaler et al., 1999)

      ommatidium

      (Kavaler et al., 1999)

      scutum & macrochaeta

      (Kavaler et al., 1999)

      scutum & macrochaeta & trichogen cell

      (Kavaler et al., 1999)

      scutum & microchaeta

      (Kavaler et al., 1999)

      scutum & microchaeta & trichogen cell

      (Kavaler et al., 1999)

      thecogen cell

      (Johnson et al., 2011)

      trichogen cell

      (Johnson et al., 2011)
      Detailed Description
      Statement
      Reference

      The nuclei of presumptive trichogen and thecogen cells of external sensory organ precursors in sv6 mutant wing imaginal discs appear smaller than that of wild-type.

      (Johnson et al., 2011)

      Homozygotes are viable as late as the pharate adult stage. sv6/Df(4)G animals show embryonic lethality. Most homozygotes die before the wandering larva stage, with the remaining few dying as pharate adults which have profound bristle defects over the entire body surface. The microchaetae and macrochaetae of the notum often have empty sockets. Macrochaetae also occasionally show a double socket phenotype. Occasionally, the anterior dorsocentral bristles (but not the posterior dorsocentral bristles) have odd shaft-like structures with no apparent socket. The neurons of the microchaetae appear normal. A mild roughening of the eye due to fusion of the ommatidia, and occasional scarring of the lens is seen. Interacts very weakly with svspa-pol.

      (Kavaler et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      P29P29, sv6 has visible | dominant phenotype

      (Kavaler et al., 1999)
      Phenotype Manifest In
      Other
      Statement
      Reference

      P29P29, sv6 has adult abdomen & macrochaeta phenotype

      (Kavaler et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      P29P29; sv6 double heterozygotes show loss of bristles on the adult abdomen.

      (Kavaler et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutation that produces loss of bristles on the adult abdomen in double heterozygous combination with P29P29.

      (Kavaler et al., 1999)
      Comments
      Comments

      The order of severity of the microchaete phenotype is: sv6 = sv7 = sv8 > svde > svn.

      (Kavaler et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sv6
      (Avetisyan et al., 2021, Johnson et al., 2011, Dziedzic et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)