Construct: A full length Hsap\LATS1 cDNA is expressed under the control of a heat shock promoter.
Hsap\LATS1hs.PT is a suppressor of hyperplasia phenotype of wtse26-1
Hsap\LATS1hs.PT is a suppressor of increased occurrence of cell division phenotype of wtse26-1
Hsap\LATS1hs.PT is a suppressor of increased body size | pupal stage phenotype of wtse26-1
Hsap\LATS1hs.PT is a suppressor of neoplasia phenotype of wtsx1
Hsap\LATS1hs.PT is a suppressor of pupa phenotype of wtse26-1
Expression of Hsap\LATS1 using heat shock in flies containing wtsx1 clones suppresses tumour formation, and the wtsx1 cells develop into normal adult structures. Homozygous wtse26-1 animals show giant pupa and disc overproliferation phenotypes. These phenotypes are partially rescued by Hsap\LATS1 at 25oC and are completely rescued by expression of Hsap\LATS1 using daily heat shock.