FB2024_03 , released June 25, 2024
Allele: Dmel\shotel3
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General Information
Symbol
Dmel\shotel3
Species
D. melanogaster
Name
FlyBase ID
FBal0095201
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
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    Progenitor genotype
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    Associated Sequence Data
    DNA sequence
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    Expression Data
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    Marker for
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    Disease-implicated variant(s)
     
    Phenotypic Data
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    Reference

    Homozygous and hemizygous embryos show a paralytic phenotype. Neuromuscular junctions occupy far less surface of their respective muscles, their branches are reduced in length and boutons appear reduced in number and size in homozygous, hemizygous and shotSF20/shotel3 embryos compared to wild-type. shotSF20/shotel3 neuromuscular junctions have excitatory junctional currents, indicating that neuromuscular transmission occurs. Peripheral nerves can form correctly in shotSF20/shotel3 embryos. The ipsilateral local arborisations of the RP3 neuron are almost normal, but the contralateral arborisations of the RP3 neuron are severely reduced and often form swellings or blobs in shotSF20/shotel3 embryos. shotSF20/shotel3 embryos do not show any obvious defects in muscle patterning at stage 16. However, at stage 17, severe detachment of the muscles from the cuticle is seen, although the muscles remain attached to each other. The thick dendrites appear collapsed and the cilia frequently appear detached from the tip of the capsule in shotSF20/shotel3 scolopidial sensory organs.

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    Complementation and Rescue Data
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    Mutant
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    Notes on Origin
    Discoverer

    Recovered as: Second-site lethal in the elB3 chromosome.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    kakel3
    shotel3
    Name Synonyms
    Secondary FlyBase IDs
      References (1)