FB2024_03 , released June 25, 2024
Allele: Dmel\stumpsUAS.cVa
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General Information
Symbol
Dmel\stumpsUAS.cVa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Vincent
FlyBase ID
FBal0094527
Feature type
allele
Associated gene
Dmel\stumps
Associated Insertion(s)
Carried in Construct
P{UAS-dof.V}
Also Known As
UAS-dof
Key Links
Transgenic product class
wild_type
(Vincent et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Vincent et al., 1998)
Mutagen
in vitro construct
(Vincent et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-dof.V}
Cytology
Description

UASt regulatory sequences drive expression of the entire coding sequence of the stumps transcript II isoform.

(Vincent et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
stumps
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of stumpsScer\UAS.cVa driven by Scer\GAL4how-24B significantly increases the number of boutons per muscle (synaptic overgrowth) at the neuromuscular junction of third instar larvae, compared to controls.

      (Sen et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of stumpsScer\UAS.cVa rescues the phenotype of reduced bouton number per muscle at the neuromuscular junction of Scer\GAL4how-24B>SmndsRNA.C.Scer\UAS.WIZ third instar larvae to control levels (and vice versa).

      (Sen et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4twi.PG/stumpsUAS.cVa rescues stumps09904b

      (Dossenbach et al., 2001)
      Partially rescues

      stumpsUAS.cVa/Scer\GAL4btl.PS partially rescues stumps09904b

      (Dossenbach et al., 2001)

      stumpsUAS.cVa/Scer\GAL4btl.PS partially rescues stumps09904b

      (Vincent et al., 1998)

      Scer\GAL4twi.PGa/stumpsUAS.cVa partially rescues stumps09904b

      (Vincent et al., 1998)
      Comments

      Expression of stumpsScer\UAS.cVa under the control of Scer\GAL4btl.PS in stumps09904b embryos rescues most aspects of tracheal patterning. The visceral branches are truncated (due to the malformation of the mesoderm in these embryos). The outline of the tracheal network in the rescue embryos is generally less well organised than in wild type and many branches do not follow their normal pathways. Expression of stumpsScer\UAS.cVa under the control of Scer\GAL4twi.PG in stumps09904b embryos fully rescues mesoderm migration and pericardial cell development.

      (Dossenbach et al., 2001)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      hbrScer\UAS.cVa
      hbrUAS.cVa
      stumpsScer\UAS.cVa
      stumpsUAS.cVa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Vincent
      (Vincent et al., 1998)
      Secondary FlyBase IDs
        References (7)