FlyBase Allele Report: Dmel\Scm[M56]

General Information

Symbol

Dmel\Scm^M56

Species

D. melanogaster

Name

FlyBase ID

FBal0094003

Feature type

allele

Associated gene

Dmel\Scm

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Bornemann et al., 1998)

Mutagen

Progenitor genotype

Cytology

Description

11bp deletion resulting in a frameshift that deletes the C-terminal half of the protein.

(Bornemann et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Bornemann et al., 1998)

Phenotype Manifest In

embryonic segment

(Bornemann et al., 1998)

Detailed Description

Statement

Reference

Homozygotes die during the embryonic or first larval instar stages. Hemizygous embryos derived from homozygous female germ line clones have all segments transformed towards the eighth abdominal segment.

(Bornemann et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scm^M56/Scm[+] is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Scm^M56 is an enhancer of visible | dominant | homeotic phenotype of Pc³

(Bornemann et al., 1998)

Suppressor of

Statement

Reference

Scm^M56/Scm[+] is a suppressor of abnormal eye color phenotype of Hsap\MECP2^R294X.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Other

Statement

Reference

Scm^M56/Scm[+], ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Scm^M56, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Scm^M56, ph-p⁴⁰⁹ has partially lethal phenotype

(Bornemann et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scm^M56/Scm[+] is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Suppressor of

Statement

Reference

Scm^M56/Scm[+] is a suppressor of eye phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Scm^M56/Scm[+] is a suppressor of eye phenotype of Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Scm^M56 is a suppressor of phenotype of z¹

(Bornemann et al., 1998)

Other

Statement

Reference

Scm^M56, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Scm^M56/Scm[+], ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Dominantly enhances the homeotic phenotypes of Pc³/+ adults. ph-p⁴⁰⁹ males that are also heterozygous for Scm^M56 show partial lethality.

(Bornemann et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Scm⁴

(Bornemann et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

M56

(Cukier et al., 2008)

Scm^M56

Scm^m56

(Gildea et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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