FlyBase Allele Report: Dmel\Src64B[Δ19]

General Information

Symbol

Dmel\Src64B^Δ19

Species

D. melanogaster

Name

FlyBase ID

FBal0093206

Feature type

allele

Associated gene

Dmel\Src64B

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Dodson et al., 1998)

Progenitor genotype

Src64B^BGT-T063

(Dodson et al., 1998)

Cytology

Description

Imprecise excision of the P{lwB} element in Src64B^BGT-T063, deleting most or all of the first 2 exons of Src64B.

(Dodson et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile | recessive

(Djagaeva, 2005, Dodson et al., 1998)

male fertile

(Dodson et al., 1998)

viable

(Djagaeva, 2005, Dodson et al., 1998)

Phenotype Manifest In

egg chamber

(Djagaeva, 2005)

nurse cell ring canal

(Dodson et al., 1998)

Detailed Description

Statement

Reference

After several generations, the fertility of Src64B^Δ19 homozygous lines increases and the number and severity of egg chamber defects decreases. 5-12% of Src64B^Δ19 mutant ovarioles contain fused egg chambers.

(Djagaeva, 2005)

Homozygous females have reduced fertility; eggs laid by these females hatch at a reduced frequency (37.9%) compared to wild-type. Stage 10A egg chambers sometimes contain fewer than 15 ring canals.

(Dodson et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Src64B^Δ19 has egg chamber phenotype, enhanceable by Btk^k05610

(Djagaeva, 2005)

Src64B^Δ19 has egg chamber phenotype, enhanceable by Btk29A[+]/Btk^k00206

(Djagaeva, 2005)

Additional Comments

Genetic Interactions

Statement

Reference

45% of Btk29A^k00206/+; Src64B^Δ19 double mutant ovarioles contain fused egg chambers and 53% of Btk29A^k05610/CyO; Src64B^Δ19 have fused chambers. Most of the fused egg chambers, and some of the unfused, display features of apoptosis.

(Djagaeva, 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Src64^Δ19

(Dodson et al., 1998)

Src64B^Δ19

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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