FB2024_03 , released June 25, 2024
Allele: Dmel\apΔHD.UAS
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General Information
Symbol
Dmel\apΔHD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0093170
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-apΔHD
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

A truncated form of ap lacking the homeodomain (truncated at amino acid 338) is expressed under the control of UAS regulatory sequences.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The ribbon-like outgrowth seen in apmd544/apP44 flies is entirely eliminated in flies expressing apΔHD.Scer\UAS under the control of Scer\GAL4ap-md544. Flies expressing apΔHD.Scer\UAS under the control of Scer\GAL4ap-md544 in an apmd544/+ background have blistered wings with numerous margin defects. The dorsal and ventral wing surfaces often fail to fuse, resulting in a fluid-filled balloon-like structure. This phenotype is rescued if the flies are also co-expressing apScer\UAS.cOa. apmd544/apts78j flies have defective wing margins and unfused wing surfaces at 18oC. Introduction of apΔHD.Scer\UAS into this background (expressed under the control of Scer\GAL4ap-md544) eliminates the wing blade altogether.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The wing pouch is a normal size in BxhdpR590 wing discs expressing apΔHD.Scer\UAS under the control of Scer\GAL4Bx-hdpR590.

Suppresses the wing phenotype of BxhdpR590 flies when expressed under the control of Scer\GAL4Bx-hdpR590.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
apΔHD.Scer\UAS
apΔHD.UAS
Name Synonyms
Secondary FlyBase IDs
    References (4)