FB2024_03 , released June 25, 2024
Allele: Dmel\commΔC.UAS
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General Information
Symbol
Dmel\commΔC.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0093115
Feature type
allele
Associated gene
Dmel\comm
Associated Insertion(s)
Carried in Construct
P{UAS-comm.ΔC}
Key Links
Transgenic product class
inframe_deletion
(Wolf et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Wolf et al., 1998)
Mutagen
in vitro construct
(Myat et al., 2002, Wolf et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-comm.ΔC}
Cytology
Description

UAS regulatory sequences drive expression of a truncated form of comm which lacks the entire cytoplasmic domain after amino acid 185.

(Wolf et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
comm
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When driven by Scer\GAL4elav-C155 the anterior and posterior commissures of the CNS appear normal.

      (Myat et al., 2002)

      The motoneuron growth cones of embryos expressing commΔC.Scer\UAS under the control of Scer\GAL4how-24B fail to initiate synaptogenesis and often stall just short of the target muscles. These phenotypes are seen in the five motoneuron nerve groups (the ISN, SNa, SNb, SNc and SNd).

      (Wolf et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4shakB.lethal.4.1/commΔC.UAS is a non-suppressor of giant fibers & dendrite phenotype of Scer\GAL4shakB.lethal.4.1, robo1UAS.cKa

      (Godenschwege et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Coexpression of commΔC.Scer\UAS, under the control of Scer\GAL4A307, with roboScer\UAS.cKa or leaScer\UAS.cSa has no effect on the robo or lea-induced giant fiber axon deflection. Coexpression of commΔC.Scer\UAS with roboScer\UAS.cKa, under the control of Scer\GAL4shakB.lethal.4.1 has no effect on the ability of robo to disrupt the dendritic guidance of the tergotrochanteral motor neurons.

      (Godenschwege et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      commΔC.Scer\UAS
      commΔC.UAS
      commΔC
      (Myat et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)