FlyBase Allele Report: Dmel\corto[l1]

General Information

Symbol

Dmel\corto^l1

Species

D. melanogaster

Name

FlyBase ID

FBal0093112

Feature type

allele

Associated gene

Dmel\corto

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Megraw and Kaufman, 1998.10.2)

visible | adult stage (with corto^07128b)

(Mouchel-Vielh et al., 2011)

visible | adult stage (with Df(3R)6-7)

(Mouchel-Vielh et al., 2011)

visible | dominant

(Rougeot et al., 2013, Mouchel-Vielh et al., 2011)

Phenotype Manifest In

wing vein | ectopic

(Rougeot et al., 2013, Mouchel-Vielh et al., 2011)

wing vein | ectopic (with corto^07128b)

(Mouchel-Vielh et al., 2011)

wing vein | ectopic (with Df(3R)6-7)

(Mouchel-Vielh et al., 2011)

Detailed Description

Statement

Reference

Over 40% of heterozygous females have an ectopic wing vein phenotype.

(Rougeot et al., 2013)

Flies carrying either corto^l1/+, corto^07128b/corto^l1 or corto^l1/Df(3R)6-7 exhibit ectopic wing veins that mainly arise close to longitudinal veins 2, 3, 5 and to the posterior cross-vein.

Flies carrying corto^l1/+ do not exhibit blistered wings.

Ectopic wing vein phenotype of corto^07128b/+ is more severe in flies heteroallelic for corto loss-of-function mutations: corto^07128b/corto^l1 and corto^l1/Df(3R)6-7.

(Mouchel-Vielh et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

corto^l1 has visible | dominant phenotype, suppressible by EloA[+]/EloA^G4930

(Rougeot et al., 2013)

corto^l1 has visible | dominant phenotype, suppressible by Elongin-B[+]/EloB^EP3132

(Rougeot et al., 2013)

corto^l1 has visible | dominant phenotype, suppressible by EloC^SH1520/l(2)SH1520[+]

(Rougeot et al., 2013)

corto^l1 has visible | dominant phenotype, suppressible by Elongin-C[+]/EloC^SH1299

(Rougeot et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

corto^l1 has wing vein | ectopic phenotype, suppressible by EloA[+]/EloA^G4930

(Rougeot et al., 2013)

corto^l1 has wing vein | ectopic phenotype, suppressible by Elongin-B[+]/EloB^EP3132

(Rougeot et al., 2013)

corto^l1 has wing vein | ectopic phenotype, suppressible by EloC^SH1520/l(2)SH1520[+]

(Rougeot et al., 2013)

corto^l1 has wing vein | ectopic phenotype, suppressible by Elongin-C[+]/EloC^SH1299

(Rougeot et al., 2013)

Enhancer of

Statement

Reference

corto[+]/corto^l1 is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic wing vein phenotype seen in corto^l1/+ females is suppressed if they are also heterozygous for one of EloA^G4930, EloB^EP3132, EloC^SH1520 or EloC^SH1299.

(Rougeot et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4788