FlyBase Allele Report: Dmel\y[2s14]

General Information

Symbol

Dmel\y^2s14

Species

D. melanogaster

Name

FlyBase ID

FBal0092417

Feature type

allele

Associated gene

Dmel\y

Associated Insertion(s)

gypsy{}y-2

P{}y-2s14

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

spontaneous

(Belenkaya et al., 1998)

P-element activity

(Belenkaya et al., 1998, Belenkaya et al., 1998)

Progenitor genotype

y²

(Belenkaya et al., 1998)

Associated Insertion(s)

gypsy{}y-2

P{}y-2s14

Cytology

Description

The lesion in y^2s20 is the same as in y^2s14.

(Belenkaya et al., 1998)

Insertion of a 1.2kb P-element 69bp upstream of the y transcription start site, together with deletion of y sequence from -146bp to -70bp. The P-element is internally deleted, containing 829bp of 5' sequence and 347bp of 3' sequence, with the filler sequence TAGCTACAAA in between. The P-element is transcribed in the opposite orientation to that of the y gene.

(Belenkaya et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:355,820..355,823 [+]

(Belenkaya et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color

(Biryukova et al., 1999, Belenkaya et al., 1998)

Phenotype Manifest In

adult cuticle

(Belenkaya et al., 1998)

wing

(Biryukova et al., 1999, Belenkaya et al., 1998)

Detailed Description

Statement

Reference

Body colour: flies have reduced pigmentation in the body cuticle and wing blade and wild-type pigmentation in the thoracic, leg, wing and abdominal bristles.

(Biryukova et al., 1999)

Body colour: pigmentation of the body and wings is reduced, pigmentation of thoracic, leg, wing and abdominal bristles is normal.

(Belenkaya et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

y^2s14 has abnormal body color phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999, Belenkaya et al., 1998)

Suppressed by

Statement

Reference

ph-p^P1, y^2s14 has abnormal body color phenotype, suppressible by sn^eP1

(Biryukova et al., 1999)

ph-p^P1, y^2s14 has abnormal body color phenotype, suppressible by Su(y)P22^P22/Su(y)P22[+]

(Biryukova et al., 1999)

ph-p^P1, y^2s14 has abnormal body color phenotype, suppressible by Su(y)P31[+]/Su(y)P31^P31

(Biryukova et al., 1999)

ph-p^P1, y^2s14 has abnormal body color phenotype, suppressible | partially by sn^wP13

(Biryukova et al., 1999)

ph-p^P1, y^2s14 has abnormal body color phenotype, suppressible | partially by sn^wP14

(Biryukova et al., 1999)

ph-p^P1, y^2s14 has abnormal body color phenotype, suppressible by su(Hw)²

(Biryukova et al., 1999)

ph-p^P1, y^2s14 has abnormal body color phenotype, suppressible by su(Hw)^V

(Biryukova et al., 1999)

NOT suppressed by

Statement

Reference

ph-p^P1, y^2s14 has abnormal body color phenotype, non-suppressible by sn^+P11

(Biryukova et al., 1999)

ph-p^P1, y^2s14 has abnormal body color phenotype, non-suppressible by sn^+P12

(Biryukova et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

y^2s14 has adult thorax & macrochaeta phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999)

y^2s14 has leg sensillum phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999)

y^2s14 has wing sensillum phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999)

y^2s14 has adult abdomen & macrochaeta phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999)

Suppressed by

Statement

Reference

y^2s14 has phenotype, suppressible by su(Hw)^V/su(Hw)²

(Belenkaya et al., 1998)

Other

Statement

Reference

ph-p^P1, y^2s14 has adult thorax & macrochaeta phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s14 has wing sensillum phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s14 has prothoracic leg sensillum phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s14 has mesothoracic leg sensillum phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s14 has metathoracic leg sensillum phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s14 has adult abdominal sensillum phenotype

(Belenkaya et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

In the presence of ph-p^P1, pigmentation of the thoracic, leg, wing and abdominal bristles is reduced. This enhancement by ph-p^P1 is completely suppressed by su(Hw)²/su(Hw)^V.

(Biryukova et al., 1999)

The phenotype is enhanced by ph-p^P1; pigmentation of thoracic, leg, wing and abdominal bristles is also reduced in y^2s14 ph-p^P1 flies. Homozygous y^2s14 females have a stronger mutant phenotype than y^2s14/y¹ females in the presence of ph-p^P1. y^2s14/y^1s8 and y^2s14/y^2s11 females have a stronger mutant phenotype than homozygous y^2s14 females in the presence of ph-p^P1.

(Belenkaya et al., 1998)

The mutant phenotype is completely suppressed by su(Hw)^V/su(Hw)².

(Belenkaya et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

y^2s14

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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