FlyBase Allele Report: Dmel\y[2s7]

Insertion of two P-element copies in head-to-head orientation 69bp upstream of the y transcription start site, together with deletion of y sequence from -146bp to -70bp. The distal P-element has normal terminal sequences, while the proximal P-element has a 5'-terminal 23bp deletion.

(Belenkaya et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:355,820..355,823 [+]

(Belenkaya et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color

(Biryukova et al., 1999, Belenkaya et al., 1998)

abnormal body color | recessive

(Belenkaya et al., 1998)

Phenotype Manifest In

adult cuticle

(Belenkaya et al., 1998, Belenkaya et al., 1998)

wing

(Biryukova et al., 1999, Belenkaya et al., 1998, Belenkaya et al., 1998)

Detailed Description

Statement

Reference

Body colour: flies have reduced pigmentation in the body cuticle and wing blade and wild-type pigmentation in the thoracic, leg, wing and abdominal bristles.

(Biryukova et al., 1999)

Body colour: pigmentation of the body and wings is reduced, pigmentation of thoracic, leg, wing and abdominal bristles is normal.

(Belenkaya et al., 1998)

The body and wings are yellow, bristles have normal pigmentation.

(Belenkaya et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

y^2s7 has abnormal body color phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999, Belenkaya et al., 1998)

Suppressed by

Statement

Reference

ph-p^P1, y^2s7 has abnormal body color phenotype, suppressible | partially by su(Hw)²

(Biryukova et al., 1999)

ph-p^P1, y^2s7 has abnormal body color phenotype, suppressible | partially by su(Hw)^V

(Biryukova et al., 1999)

NOT suppressed by

Statement

Reference

ph-p^P1, y^2s7 has abnormal body color phenotype, non-suppressible by sn^eP1

(Biryukova et al., 1999)

ph-p^P1, y^2s7 has abnormal body color phenotype, non-suppressible by Su(y)P22^P22

(Biryukova et al., 1999)

ph-p^P1, y^2s7 has abnormal body color phenotype, non-suppressible by Su(y)P31^P31

(Biryukova et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

y^2s7 has wing phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999, Belenkaya et al., 1998)

y^2s7 has adult thorax & macrochaeta phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999)

y^2s7 has leg sensillum phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999)

y^2s7 has wing sensillum phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999)

y^2s7 has adult abdomen & macrochaeta phenotype, enhanceable by ph-p^P1

(Biryukova et al., 1999)

y^2s7 has adult cuticle phenotype, enhanceable by ph-p^P1

(Belenkaya et al., 1998)

Suppressed by

Statement

Reference

y^2s7 has adult cuticle phenotype, suppressible by su(Hw)^V/su(Hw)²

(Belenkaya et al., 1998)

y^2s7 has wing phenotype, suppressible by su(Hw)^V/su(Hw)²

(Belenkaya et al., 1998)

Other

Statement

Reference

ph-p^P1, y^2s7 has adult thorax & macrochaeta phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s7 has wing sensillum phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s7 has prothoracic leg sensillum phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s7 has mesothoracic leg sensillum phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s7 has metathoracic leg sensillum phenotype

(Belenkaya et al., 1998)

ph-p^P1, y^2s7 has adult abdominal sensillum phenotype

(Belenkaya et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The phenotype is enhanced by ph-p^P1; y expression is completely inhibited. This enhancement by ph-p^P1 is weakly suppressed by su(Hw)²/su(Hw)^V.

(Biryukova et al., 1999)

The phenotype is enhanced by ph-p^P1; pigmentation of the body and wings is further reduced, and pigmentation of thoracic, leg, wing and abdominal bristles is also reduced in y^2s7 ph-p^P1 flies.

(Belenkaya et al., 1998)

The mutant phenotype is completely suppressed by su(Hw)^V/su(Hw)².

(Belenkaya et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

y^2s7

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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