FB2024_03 , released June 25, 2024
Allele: Dmel\Mer1-600.UAS.Tag:MYC
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General Information
Symbol
Dmel\Mer1-600.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0091717
Feature type
allele
Associated gene
Dmel\Mer
Associated Insertion(s)
Carried in Construct
P{UAS-Mer1-600.myc}
Also Known As
Mer1-600
Key Links
Transgenic product class
inframe_deletion
(LaJeunesse et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(LaJeunesse et al., 1998)
Mutagen
in vitro construct
(LaJeunesse et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-Mer1-600.myc}
Cytology
Description

Mer amino acids 1 to 600, tagged at the N-terminal end with Tag:MYC, are expressed under the control of UASt regulatory sequences.

(LaJeunesse et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mer
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mer1-600.Scer\UAS.T:Hsap\MYC in wild-type wings (under the control of Scer\GAL4ap-md544) causes a reduction in size by a mean of 15% from wild-type.

      (Hughes and Fehon, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Mer1-600.UAS.Tag:MYC, Scer\GAL4ap-md544 has wing phenotype, enhanceable by slik[+]/Slik1

      (Hughes and Fehon, 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Reduction of slik in a slik1/+ background reduces wing size by a mean of 18% in flies expressing Mer1-600.Scer\UAS.T:Hsap\MYC (under the control of Scer\GAL4ap-md544) compared to wild-type flies (and compared to a 15% reduction in Mer1-600.Scer\UAS.T:Hsap\MYC/Scer\GAL4ap-md544 flies).

      (Hughes and Fehon, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Mer1-600.UAS.Tag:MYC/Scer\GAL4T80 rescues Mer4

      (LaJeunesse et al., 1998)
      Comments

      Rescues the lethality of Mer4 hemizygous males when expressed under the control of Scer\GAL4T80.

      (LaJeunesse et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mer1-600.Scer\UAS.T:Hsap\MYC
      Mer1-600.UAS.T:Myc
      Mer1-600.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (4)