FlyBase Allele Report: Dmel\Abl[EP3101]

General Information

Symbol

Dmel\Abl^EP3101

Species

D. melanogaster

Name

FlyBase ID

FBal0089850

Feature type

allele

Associated gene

Dmel\Abl

Associated Insertion(s)

P{EP}Abl^EP3101

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Rorth et al., 1998)

Progenitor genotype

Associated Insertion(s)

P{EP}Abl^EP3101

Cytology

Description

The P{EP} element is inserted 132 nucleotides 5' to the predicted ATG start codon.

(Kraut et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:16,647,298..16,647,298 [-]

(Jhaveri et al., 2004, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Bashaw et al., 2000, Rorth et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with Abl⁴)

(Lin et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Bouton number per muscle area is significantly increased at the larval neuromuscular junction in Abl^EP3101/Abl⁴ mutants compared to controls.

(Lin et al., 2009)

The antennal lobes of Abl^EP3101; Scer\GAL4^SG18.1 flies glomerular patterning is significantly disrupted, and while the antennal commissure is present, its axons are loosely fasciculated.

(Jhaveri et al., 2004)

Mutant larvae expressing Abl^EP3101 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects. An ISNb fusion bypass phenotype is seen.

(Kraut et al., 2001)

Abl^EP3101 when driven by Scer\GAL4^elav-C155 causes pathfinding errors of an entire nerve branch a ISNb fusion bypass phenotype is seen in which ISNb fails to defasciculate from the ISN and muscle 13 is innervated by an abnormal side branch.

(Kraut et al., 2001)

When Abl^EP3101 is expressed under the control if Scer\GAL4^elav.PLu or Scer\GAL4^sca-537.4, the bundles of longitudinal connectives of the medial pathway ectopically crosses the midline, in a dose dependant manner.

(Bashaw et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Abl^EP3101/Scer\GAL4^slbo.2.6 is a suppressor of female fertile phenotype of slbo⁰¹³¹⁰

(Rorth et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Abl^EP3101, Scer\GAL4^elav.PLu has larval longitudinal connective phenotype, enhanceable by sli²/sli[+]

(Bashaw et al., 2000)

Abl^EP3101, Scer\GAL4^elav.PLu has larval longitudinal connective phenotype, enhanceable by robo[+]/robo1¹

(Bashaw et al., 2000)

NOT Enhanced by

Statement

Reference

Abl^EP3101, Scer\GAL4^elav.PLu has larval longitudinal connective phenotype, non-enhanceable by ena[+]/ena^GC1

(Bashaw et al., 2000)

Enhancer of

Statement

Reference

Abl^EP3101, robo1⁵, Scer\GAL4^elav.PLu is an enhancer of larval longitudinal connective phenotype of sli¹

(Bashaw et al., 2000)

Abl^EP3101/Scer\GAL4^elav.PLu is an enhancer of larval longitudinal connective phenotype of robo1⁵, sli[+]/sli¹

(Bashaw et al., 2000)

Suppressor of

Statement

Reference

Abl^EP3101/Scer\GAL4^slbo.2.6 is a suppressor of border follicle cell phenotype of slbo⁰¹³¹⁰

(Rorth et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of robo¹/+, or sli² to Abl^EP3101,Scer\GAL4^elav.PLu flies, markedly enhances the midline crossing defects seen in these embryos.

(Bashaw et al., 2000)

Suppresses the sterility and abnormal border follicle cell migration phenotype of slbo⁰¹³¹⁰ females when expressed under the control of Scer\GAL4^slbo.2.6.

(Rorth et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Abl^EP3101

(Lin et al., 2009)

EPabl

(Bashaw et al., 2000)

abl^EP31010

(Jhaveri et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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