FB2024_03 , released June 25, 2024
Allele: Dmel\timmTim4
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General Information
Symbol
Dmel\timmTim4
Species
D. melanogaster
Name
FlyBase ID
FBal0088575
Feature type
allele
Associated gene
Dmel\tim
Associated Insertion(s)
Carried in Construct
P{Tim4}
Also Known As
Tim 4, P[LS-tim]
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Ousley et al., 1998)
Progenitor genotype
Carried in construct
P{Tim4}
Cytology
Description

A 4.5kb genomic fragment extending from approximately -4300 to +180bp relative to the tim transcription start site is fused to a tim cDNA which includes a 32 amino acid sequence within the N-terminal region (this sequence is not present in timmTim1).

(Ousley et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
tim
tim_tim-4
Encoded product / tool
tim
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing timmTim4 adjust their locomotor activity rhythms earlier than control flies.

      Temperature-mediated molecular re-entrainment is faster in flies expressing timmTim4.

      (Goda et al., 2014)

      timmTim4 flies kept in constant light conditions show locomotor arrhythmicity, as do wild-type flies.

      (Sandrelli et al., 2007)

      Females carrying the timmTim4 transgene do not show the high levels of diapause that tim01 females show.

      (Tauber et al., 2007)

      timmTim4 does not affect normal circadian rhythms in a wild-type background.

      (Ashmore et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      timmTim4 is a non-enhancer of abnormal circadian rhythm phenotype of pertim.Aa

      (Ashmore et al., 2003)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of timmTim4 into flies with a pertim.Aa background does not further shorten the circadian period of flies.

      (Ashmore et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      timmTim4 rescues tim01

      (Ashmore et al., 2003)
      Partially rescues

      timmTim4 partially rescues tim01

      (Ousley et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tim 4
      (Goda et al., 2014)
      timmTim4
      Name Synonyms
      Secondary FlyBase IDs
        References (9)