FB2024_03 , released June 25, 2024
Allele: Dmel\shgunspecified
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General Information
Symbol
Dmel\shgunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086342
Feature type
allele
Associated gene
Dmel\shg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Zygotic mutant embryos have cuticle defects, although large patches of cuticle remain.

        (Houssin et al., 2015)

        shgunspecified mutant embryos have many holes in the cuticle, which have necrotic rims. The head is grossly distorted.

        (Tearle and Nusslein-Volhard, 1987)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        shg[+], CadN[+], CadNunspecified, shgunspecified is an enhancer of decreased cell number | adult stage phenotype of jusiso7.8

        (Lim et al., 2015)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Cuticle is almost completely absent in embryos that are zygotically mutant for shg and both maternally and zygotically mutant for Girdin.

        (Houssin et al., 2015)

        CadNunspecified/+, shgunspecified/+; sdaiso7.8/+ mutants display a more severe decrease in numbers of hub cells, germline stem cells and cyst stem cells in the testicular niche as compared with sdaiso7.8/+ mutants.

        (Lim et al., 2015)

        Marked clones in the eye disc expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act5C.PI and which are also homozygous for shgunspecified do not show metastatic behaviour, although the cells cause disc eversion defects during metamorphosis.

        (Pagliarini and Xu, 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        shgunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (5)