FB2024_03 , released June 25, 2024
Allele: Dmel\GluRIIAMhc.Tag:MYC
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General Information
Symbol
Dmel\GluRIIAMhc.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0085983
Feature type
allele
Associated gene
Dmel\GluRIIA
Associated Insertion(s)
Carried in Construct
P{Mhc.GluRIIA.Myc}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Davis et al., 1998, Petersen et al., 1997)
Progenitor genotype
Carried in construct
P{Mhc.GluRIIA.Myc}
Cytology
Description

A Tag:MYC epitope has been incorporated immediately following a heterologous signal sequence used to replace the endogenous signal sequence. This epitope is present at the extracellular N-terminus of the receptor coding region. Expression is driven by Mhc promoter sequences.

(Petersen et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
Mhc
Encoded product / tool
GluRIIA
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter or direct label
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      muscle cell of ventral cervical muscle 26
      (Rivlin et al., 2004)
      muscle cell of prothoracic sternal adductor muscle 33
      (Rivlin et al., 2004)
      adult somatic muscle cell of abdomen
      (Rivlin et al., 2004)
      day 3 of adulthood
      muscle cell of ventral cervical muscle 25
      (Rivlin et al., 2004)
      Additional Information
      Statement
      Reference

      In the adult prothorax and neck, Myc-tagged GluRIIA protein is observed at the type I boutons of motor neurons innervating ventral cervical muscle 25 and prothoracic sternal adductor muscle 33 from the first day of adulthood, and ventral cervical muscle 26 from the third day of adulthood. GluRIIA protein is also observed at the type I boutons of all adult abdominal muscles. GluRIIA protein is not detected in Type II boutons.

      (Rivlin et al., 2004)
       
      Marker for
      Reflects expression of
      GluRIIA
      (Rivlin et al., 2004)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      GluRIIAMhc.Tag:MYC is a non-suppressor of lethal | recessive | embryonic stage phenotype of GluRIID1

      (Featherstone et al., 2005)

      GluRIIAMhc.Tag:MYC is a non-suppressor of paralytic | recessive phenotype of GluRIID1

      (Featherstone et al., 2005)

      GluRIIAMhc.Tag:MYC is a non-suppressor of lethal | recessive | embryonic stage phenotype of GluRIID2

      (Featherstone et al., 2005)

      GluRIIAMhc.Tag:MYC is a non-suppressor of paralytic | recessive phenotype of GluRIID2

      (Featherstone et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The larval locomotion deficit (reduced crawling ability) characteristic for Msp300ΔKASH mutant third instar larvae is significantly rescued by combination with GluRIIAMhc.T:Hsap\MYC but only in about 60% of the larvae, the remaining 40% show no improvement of the locomotion phenotype.

      (Morel et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Glu-RIIAMhc.T:Hsap\MYC
      Glu-RIIAMhc.T:Myc
      GluRIIAMhc.T:Hsap\MYC
      GluRIIAMhc.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (11)