FB2024_03 , released June 25, 2024
Allele: Dmel\N::torUAS.cSa
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General Information
Symbol
Dmel\N::torUAS.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Seugnet
FlyBase ID
FBal0085944
Feature type
allele
Associated gene
N::tor
Associated Insertion(s)
Carried in Construct
P{torso4021-Notch}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Seugnet et al., 1997)
Progenitor genotype
tor13D
(Seugnet et al., 1997)
Carried in construct
P{torso4021-Notch}
Cytology
Description

UASt regulatory sequences drive expression of a constitutively active, ligand-independent form of N. It is composed of the extracellular and transmembrane domain of tor13D fused at Cys420 of tor to Gln1787 of the intracellular domain of N.

(Seugnet et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
N::tor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of N::torScer\UAS.cSa under the control of Scer\GAL4dpp.blk1 results in a slight reduction in the overall size of the wing pouch region in the wing disc.

      (Hayward et al., 2005)

      When expression is driven by Scer\GAL4da.G32 in a wild type background, the resulting phenotype resembles that of puc1 mutants.

      (Zecchini et al., 1999)

      Scer\GAL4pnr-MD237- or Scer\GAL4410.2-mediated expression suppresses the formation of bristle precursors in a wild type background.

      (Seugnet et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      N::torScer\UAS.cSa cannot rescue a complete loss of function of N.

      The change in wing disc shape caused by expression of armS10.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dpp.blk1 is significantly suppressed by co-expression of N::torScer\UAS.cSa.

      (Hayward et al., 2005)

      Expression driven by Scer\GAL4da.G32 partially rescues the neurogenic phenotype of N mutants, with rescue only evident on the dorsal surface of the embryos.

      (Zecchini et al., 1999)

      Scer\GAL4pnr-MD237- or Scer\GAL4410.2-mediated expression suppresses the formation of bristle precursors in a shi mutant background, but not N mutants.

      (Seugnet et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      N::torScer\UAS.cSa
      N::torUAS.cSa
      TNotch
      (Hayward et al., 2005)
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Seugnet
      (Seugnet et al., 1997)
      Secondary FlyBase IDs
        References (3)