FB2024_03 , released June 25, 2024
Allele: Dmel\hhCD2.UAS
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General Information
Symbol
Dmel\hhCD2.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0082885
Feature type
allele
Associated gene
Dmel\hh
Associated Insertion(s)
Carried in Construct
P{UAS-hhCD2}
Also Known As
UAS-Hh-CD2, UAS-hhCD2, UAS-hh-N-CD2, UAS-Hh:CD2
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Strigini and Cohen, 1997)
Progenitor genotype
Carried in construct
P{UAS-hhCD2}
Cytology
Description

UASt regulatory sequences drive expression of a membrane-tethered form of hh. This consists of the hh signalling fragment fused to the coding sequence of Rnor\Cd2 (excluding the signal peptide and first amino acid, but including the transmembrane domain).

(Strigini and Cohen, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
hh
Tagged with
Tag:M(rCd2)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of hhSF.Scer\UAS.T:Rnor\CD2 in the ventral nerve cord of wild-type embryos, under the control of Scer\GAL4insc-Mz1407 results in the abrogation of ganglionic branch migration/extension and in earlier expression of bs.

      (Butí et al., 2014)

      Expression of hhSF.Scer\UAS.T:Rnor\CD2, under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C in hhAC mutants only rescues type 1 and adjacent type 2 cuticles, but not the distant type 3 cuticle, In addition, the type 2 cuticle domain is more restricted than it is in wild-type embryos.

      (Gallet et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4en-e16E, hhCD2.UAS, hhts2 has wing disc phenotype, non-suppressible by dispS037707

      (Burke et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ability of hhSF.Scer\UAS.T:Rnor\CD2 to rescue the growth defects of hhts2 wing imaginal discs when expressed under the control of Scer\GAL4en-e16E is unaffected if the discs are also homozygous for dispS037707.

      (Burke et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Naked cuticle formation in hhAC/hhAC embryos is not rescued by hhC85S.Scer\UAS; Scer\GAL469B. However the denticle lawn formed, is transformed from row 5 type, to bands of row 3 type denticles, separated by a single row 4 + an incomplete row 5.

      (Gallet et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      hhCD2.UAS
      hhSF.Scer\UAS.T:Rnor\CD2
      hhSF.UAS.T:CD2
      Name Synonyms
      Secondary FlyBase IDs
        References (17)