FlyBase Allele Report: Dmel\vg[83b27-R]

General Information

Symbol

Dmel\vg^83b27-R

Species

D. melanogaster

Name

FlyBase ID

FBal0082055

Feature type

allele

Associated gene

Dmel\vg

Associated Insertion(s)

Carried in Construct

Also Known As

vg^83b27R

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Williams et al., 1993, Williams et al., 1990)

Mutagen

gamma ray

(Williams et al., 1990)

Progenitor genotype

vg^83b27

(Williams et al., 1990)

Cytology

Description

Mutation has the original vg^83b27 deletion and a second deletion similar in size and location to that of vg^nw.

(Williams et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Williams et al., 1990)

visible | recessive

(Williams et al., 1993)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous clones are rarely recovered in the wing blade region of the wing disc.

(Wu et al., 2008)

Mature mutant wing discs lack the wing primordium.

(Zecca and Struhl, 2007)

The dorsal/ventral compartment boundary is only slightly disturbed in vg^null/vg^83b27-R wing discs.

(Koelzer and Klein, 2006)

Homozygous clones induced in the second larval instar cause a dramatic reorganisation of cell fate in the distal wing, including the induction of epithelial folds that are reminiscent of the hinge.

(Zirin and Mann, 2004)

Of the indirect flight muscles in vg^83b27-R mutants, the dorsal medial muscles are severely reduced and the dorso-ventral muscles (lateral oblique dorsal muscles and tergosternal muscles) are minimal or completely missing (10/10 examined).

(Sudarsan et al., 2001)

Homozygous clones in the wing disc are infrequent and round, suggesting that they sort out from surrounding wild-type cells.

(Azpiazu and Morata, 2000)

Mutants exhibit a severely reduced hinge and sometimes lack both the blade and the hinge and display wing to notum transformations.

(Klein and Martinez Arias, 1998)

vg^WR2 produces an extreme vg phenotype in combination with vg^83b27-R; all adult structures derived from the wing discs, including the notum, are deleted.

(Simmonds and Bell, 1998)

Clones induced in the wing disc are readily recovered in the notum but not in the wing disc. At most two- or three-cell clones can be found in the developing wing pouch.

(Kim et al., 1996)

Wing structures eliminated, retaining only a small amount of wing hinge.

(Williams et al., 1993)

Display erect postscutellar bristles and extreme wing phenotype.

(Williams et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

vg^83b27-R is a suppressor of increased cell number | somatic clone phenotype of Scer\GAL4^Act5C.PP, tkv^{Q253D.UAS.cNc}

(Martin-Castellanos and Edgar, 2002)

vg^83b27-R is a suppressor of increased occurrence of cell division | somatic clone | larval stage phenotype of Scer\GAL4^Act5C.PP, tkv^{Q253D.UAS.cNc}

(Martin-Castellanos and Edgar, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

vg^83b27-R, vg^UAS.cKa has wing phenotype, enhanceable by Scer\GAL4^dpp.blk1/Ser^UAS.cSa

(Klein and Martinez Arias, 1998)

NOT Enhanced by

Statement

Reference

vg^83b27-R has wing phenotype, non-enhanceable by Scer\GAL4^dpp.blk1/Ser^UAS.cSa

(Klein and Martinez Arias, 1998)

Suppressed by

Statement

Reference

vg^83b27-R has wing pouch | somatic clone phenotype, suppressible by yki^UAS.cHa/Scer\GAL4^Tub.PU

(Wu et al., 2008)

NOT suppressed by

Statement

Reference

vg^83b27-R has wing phenotype, non-suppressible by wg^UAS.cGa/Scer\GAL4^dpp.blk1

(Klein and Martinez Arias, 1998)

vg^83b27-R has wing phenotype, non-suppressible by Scer\GAL4^dpp.blk1/wg^l-12.UAS

(Klein and Martinez Arias, 1998)

Other

Statement

Reference

Scer\GAL4^dpp.blk1, Ser^UAS.cSa, vg^83b27-R, vg^UAS.cKa has wing phenotype

(Klein and Martinez Arias, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous vg^83b27-R clones that are also expressing yki^Scer\UAS.cHa under the control of Scer\GAL4^tub.PU are readily recovered in the wing blade region of the wing disc.

(Wu et al., 2008)

When tkv^{Q253D.Scer\UAS.cNc} is driven by Scer\GAL4^Act5C.PP in a vg^83b27-R background, complete suppression of the proliferation phenotype is seen.

(Martin-Castellanos and Edgar, 2002)

Expression of Ser^Scer\UAS.cSa does not cause ectopic wing margin formation, but mediated coexpression with vg^Scer\UAS.cKa leads to significant induction of an ectopic wing margin. Scer\GAL4^dpp.blk1-mediated expression of wg^Scer\UAS.cGa or wg^{l-12.Scer\UAS} fails to rescue loss of wing tissue.

(Klein and Martinez Arias, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

vg^83b27-R is rescued by vg^αTub84B.PZa

(Zecca and Struhl, 2007)

vg^83b27-R is rescued by vg^5XQE.cZa

(Zecca and Struhl, 2007)

vg^83b27-R is rescued by Scer\GAL4^dpp.blk1/vg^UAS.cKa

(Klein and Martinez Arias, 1998)

Partially rescued by

vg^83b27-R is partially rescued by vg^Δ1-4.UAS/Scer\GAL4^vg.PM

(MacKay et al., 2003)

vg^83b27-R is partially rescued by vg^Δ7-8.UAS/Scer\GAL4^vg.PM

(MacKay et al., 2003)

vg^83b27-R is partially rescued by Scer\GAL4^vg.PM/vg^UAS.cKa

(MacKay et al., 2003)

Not rescued by

vg^83b27-R is not rescued by vg^RpL32.PZ

(Zecca and Struhl, 2007)

Comments

Scer\GAL4^dpp.blk1-mediated expression of vg^Scer\UAS.cKa rescues the wing margin. Expression does not cause ectopic wing margin formation.

(Klein and Martinez Arias, 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Lost complementation ability of vg^83b27.

(Williams et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

vg⁰

(Zecca and Struhl, 2007)

vg^83b27-R

(Dubois et al., 2007, Félix et al., 2007)

vg^83b27r

(Benito-Sipos et al., 2010, Cho and Irvine, 2004, Wu and Cohen, 2002)

Name Synonyms

Secondary FlyBase IDs

References (28)

Report Sections

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