FB2024_03 , released June 25, 2024
Allele: Dmel\mr5
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General Information
Symbol
Dmel\mr5
Species
D. melanogaster
Name
FlyBase ID
FBal0065730
Feature type
allele
Associated gene
Dmel\mr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Reed and Orr-Weaver, 1997)
Progenitor genotype
Cytology
Description

Nucleotide substitution at a splice acceptor site after the sixth intron that should remove the C-terminus of the protein from Glu-657 onwards.

(Kashevsky et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:23,974,840..23,974,840 [+]
Comment:

An unspecified mutation in the splice acceptor site. The splice site mutation has been arbitrarily mapped by a FlyBase curator to the first base of the splice acceptor site.

(Kashevsky et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larval brain neuroblasts show metaphase block, and have highly overcondensed chromosomes and frequent polyploid figures. Mosaic females in which the germ cells are homozygous for mr5 sometimes have inappropriate spindles and metaphase-like chromosomes in stage 4 egg chambers. Mosaic adults can have rough eyes and reduced bristles, and patches of metaphase-arrested mitotic figures are seen in the brains of mosaic larvae.

      (Reed and Orr-Weaver, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      mr4 and mr5 have the same lesion and were recovered from the same screen, and likely represent isolates from the same premeiotic event.

      (Kashevsky et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mr5
      Name Synonyms
      Secondary FlyBase IDs
        References (2)