FB2024_03 , released June 25, 2024
Allele: Dmel\EcRk06210
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General Information
Symbol
Dmel\EcRk06210
Species
D. melanogaster
Name
FlyBase ID
FBal0065262
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Insertion maps within first exon of CG14589 which itself maps within EcR.

A P{lacW} insertion between EcR-A exon3 and EcR-B1/B2 transcription start.

Allele components
Component
Use(s)
Inserted element
Encoded product / tool
Mutations Mapped to the Genome
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant pharate adults show a bent leg phenotype.

No eye phenotype is seen in these mutants.

2/3 of homozygotes die as pharate adults, while the remainder survive to adulthood. These adults die after about 1 week at 25oC, but are fertile and can survive up to three weeks at 18oC. These flies also exhibit cell adhesion and morphogenetic defects. 1/4 display venation defects, 1/3 display wing blisters. These blisters are usually small and centrally located, although blistering of the whole wing (a balloon wing) can occasionally be seen. The most frequent venation defects include a small, extra vein that originates from the third longitudinal vein, an additional anterior crossvein, and a "delta" thickening at the intersection between the posterior crossvein and the fourth longitudinal vein. EcRk06210/EcRM554fs flies are fully lethal. FlyBase curator comment: Since the "k06210" insertion lies within EcR and the EcR-intronic CG14589 it is not clear which disruption might be responsible for the lethality.

FlyBase curator comment: Since the "k06210" insertion lies within EcR and the EcR-intronic CG14589 it is not clear which disruption might be responsible for the lethality.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

EcRk06210/EcR[+] is a suppressor of eye disc morphogenetic furrow phenotype of trr4

EcRk06210/EcR[+] is a suppressor of ommatidium phenotype of trr4

EcRk06210/EcR[+] is a suppressor of eye phenotype of trr4

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Complements: jing01094. Complements: l(2)0531505315. Complements: l(2)k03204k03204. Complements: l(2)k09848k09848. Complements: Src42Ak10108. Complements: l(2)k14710k14710. Complements: l(2)k14805k14805. Complements: l(2)k14710k15603. Fails to complement: esgk05332b.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (8)