FlyBase Allele Report: Dmel\Khc[k13314]

General Information

Symbol

Dmel\Khc^k13314

Species

D. melanogaster

Name

FlyBase ID

FBal0064139

Feature type

allele

Associated gene

Dmel\Khc

Associated Insertion(s)

P{lacW}Khc^k13314

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Khc^k13314

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:16,271,763..16,271,763 [-]

(Li et al., 2017, Whited et al., 2004, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | recessive

(Medina et al., 2008)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

dendrite

(Medina et al., 2008)

Detailed Description

Statement

Reference

Homozygous mutants have swelling in the dendrites.

(Medina et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Khc^k13314 has abnormal neuroanatomy phenotype, enhanceable by punc[+]/capt^K304

(Medina et al., 2008)

Enhancer of

Statement

Reference

Khc^k13314 is an enhancer of abnormal neuroanatomy phenotype of capt^K304

(Medina et al., 2008)

Other

Statement

Reference

Khc^k13314, punc[+]/capt^K304 has abnormal neuroanatomy phenotype

(Medina et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Khc^k13314 has dendrite phenotype, enhanceable by capt^K304

(Medina et al., 2008)

Enhancer of

Statement

Reference

Khc^k13314 is an enhancer of dendrite phenotype of capt^K304

(Medina et al., 2008)

Suppressor of

Statement

Reference

Khc[+]/Khc^k13314 is a suppressor | partially of larval Bolwig's organ & nucleus phenotype of DCTN1-p150^Δ.UAS, Scer\GAL4^elav.PLu

(Whited et al., 2004)

Khc[+]/Khc^k13314 is a suppressor of eye photoreceptor cell & nucleus phenotype of DCTN1-p150^Δ.UAS, Scer\GAL4^Glass38-1

(Whited et al., 2004)

Khc[+]/Khc^k13314 is a suppressor of eye photoreceptor cell & nucleus phenotype of DCTN1-p150^Gl-1

(Whited et al., 2004)

Khc[+]/Khc^k13314 is a suppressor of eye phenotype of DCTN1-p150^Gl-1

(Whited et al., 2004)

Khc[+]/Khc^k13314 is a suppressor of ommatidium phenotype of DCTN1-p150^Gl-1

(Whited et al., 2004)

Other

Statement

Reference

Khc^k13314, capt^K304 has dendrite phenotype

(Medina et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Khc^k13314 capt^K304 double heterozygotes have swelling in the dendrites (this phenotype is not seen in either single heterozygote).

capt^K304 Khc^k13314 double homozygotes show a higher frequency of Act5C^{Scer\UAS.T:Avic\GFP} puncta in the dendrites and dendritic swellings than seen in either the capt^K304 or Khc^k13314 single homozygotes respectively. In addition, the double homozygotes show formation of elongate actin rods (expressing Act5C^{Scer\UAS.T:Avic\GFP}), a phenotype that is not seen in either single homozygote.

(Medina et al., 2008)

The Gl¹/+ adult eye phenotype and the loss of photoreceptor nuclei from the retina in late third instar Gl¹/+ larvae are partially suppressed by Khc^k13314/+. The loss of photoreceptor nuclei from the retina in late third instar Gl^Δ.Scer\UAS; Scer\GAL4^Glass38-1 larvae is significantly suppressed by Khc^k13314/+. Mislocalisation of the Bolwig's organ nuclei in Gl^Δ.Scer\UAS/Scer\GAL4^elav.PLu second instar larvae is partially suppressed by Khc^k13314/+ .

(Whited et al., 2004)

S^48-5/Khc^k13314 mutants show 2.87%+-2.04 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11084

y¹ w^67c23; P{lacW}Khc^k13314/CyO

Kyoto

111322

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Khc^k13314 /CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Complements: l(2)k11702^k11702. Complements: Lis-1^k13209.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Khc^k13314

khc-k13314

(Gaengel and Mlodzik, 2003)

khc^k13314

(Li et al., 2017, Medina et al., 2008, Janody and Treisman, 2006)

l(2)13314

(Spradling et al., 1999)

l(2)k13314^k13314

(BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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