FlyBase Allele Report: Dmel\babo[k07737]

General Information

Symbol

Dmel\babo^k07737

Species

D. melanogaster

Name

FlyBase ID

FBal0064036

Feature type

allele

Associated gene

Dmel\babo

Associated Insertion(s)

P{lacW}babo^k07737

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Brummel et al., 1999)

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}babo^k07737

Cytology

Description

P{lacW} maps to the 5' untranslated region of the babo transcript at base 25.

(Brummel et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:8,952,367..8,952,367 [+]

(Brummel et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Brummel et al., 1999, Spradling et al., 1999)

Phenotype Manifest In

adult head capsule (with Df(2R)Np1)

(Shyamala and Bhat, 2002)

adult head capsule (with Df(2R)Np3)

(Shyamala and Bhat, 2002)

anal pad

(Brummel et al., 1999)

embryonic/larval anterior spiracle

(Brummel et al., 1999)

larva

(Brummel et al., 1999)

Detailed Description

Statement

Reference

100% of babo^k07737/Df(2R)Np3 or babo^k07737/Df(2R)Np3 animals exhibit head capsule defects.

(Shyamala and Bhat, 2002)

Homozygous larvae show slowed development and enlarged anal pads. A significant fraction pupate and survive to pharate adults with normal thoracic cuticle and appendages but defective abdominal cuticle, suggestive of a histoblast disorder. Larvae do not leave food and do not evert their anterior spiracles. Homozygous clones of adult tissue (wing and leg) show no mutant phenotype.

(Brummel et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Df(2R)Np3/babo^k07737 has adult head capsule phenotype, non-suppressible by smo¹

(Shyamala and Bhat, 2002)

Other

Statement

Reference

babo^k07737, ptc^H84, smo¹ has adult head capsule phenotype

(Shyamala and Bhat, 2002)

babo^k07737, ptc^H84, smo¹/smo[+] has adult head capsule phenotype

(Shyamala and Bhat, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

10% of ptc^H84, smo¹/+, babo^k07737 animals exhibit head capsule defects. 10% of ptc^H84, smo¹/+, babo^k07737 animals exhibit head capsule defects. The addition of smo¹ to babo^k07737/Df(2R)Np3 animals has no effect on head capsule defects.