FB2024_03 , released June 25, 2024
Allele: Dmel\gsb525
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General Information
Symbol
Dmel\gsb525
Species
D. melanogaster
Name
FlyBase ID
FBal0062814
Feature type
allele
Associated gene
Dmel\gsb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Duman-Scheel et al., 1997)
Mutagen
ethyl methanesulfonate
(Seeger et al., 1993)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Duman-Scheel et al., 1997)

Amino acid replacement: Q185term.

(Duman-Scheel et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:25,063,731..25,063,731 [+]
Nucleotide change:

C25063731T

Reported nucleotide change:

C?T

Amino acid change:

Q185term | gsb-PA

Reported amino acid change:

Q185term

(Duman-Scheel et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The development of the visceral mesoderm, the somatic mesoderm and fat body morphology is normal in gsb525 mutants. In gsb525 and gsb525/Df(2R)gsb embryos, the salivary glands invaginate and turn posteriorly as in wild-type embryos, but become misorientated and kinked. The distal tips of the glands are usually oriented ventrally, instead of being elongated along the anterior-posterior axis.

      (Vining et al., 2005)

      Mutants occasionally have subtle cuticle defects. Mutants have duplicated RP2 neurons (the entire NB 4-2 lineage is duplicated) and lack U and CQ neurons. Posterior commissures are missing or reduced, phenotype varies between segments but no segment is wild type. Double mutants with ptc9 or wgl-17 exhibit duplicated RP2 and RP2 sibling neurons.

      (Duman-Scheel et al., 1997)

      Missing or reduced posterior commissures.

      (Seeger et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      gsb525 is rescued by gsb+t20.1

      (Duman-Scheel et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      gsb-d525
      (Duman-Scheel et al., 1997)
      gsb525
      (Bivik et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)