FB2024_03 , released June 25, 2024
Allele: Dmel\y+s
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General Information
Symbol
Dmel\y+s
Species
D. melanogaster
Name
FlyBase ID
FBal0062346
Feature type
allele
Associated gene
Dmel\y
Associated Insertion(s)
gypsy{}y-2
P{}y+s-a
P{}y+s-b
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Georgiev et al., 1997)
Progenitor genotype
y2
(Georgiev et al., 1997)
Associated Insertion(s)
gypsy{}y-2
P{}y+s-a
P{}y+s-b
Caused by aberration
Tp(1;1)y+s
Cytology
Description

Contains a pair of 1.2kb P-elements with a duplicated 2.9kb genomic sequence (containing anon-1Ab) inserted between them.

(Biryukova et al., 1999)

5.3kb insertion 69bp upstream of the y transcription start site. The insertion contains a central region of 2.9kb genomic DNA flanked by two copies of a 1.2kb deleted P-element, which are arranged in opposite orientations. The direction of transcription of the P-element that is most proximal to the y transcription start site is the same as that of the y gene, while the direction of transcription of the P-element that is most distal to the y transcription start site is opposite to that of the y gene. Neither the whole insertion nor the individual P-elements are flanked by the characteristic base pair duplications that are normally found after P-element insertion. The 2.9kb genomic fragment that is flanked by the P-elements includes sequences that originate from region 1A of the X chromosome in close proximity and distal to the y locus, and some repetitive sequences. It also contains a small putative gene (anon-1Ab) flanked by a TATA box and a polyadenylation site. The gypsy element present in the progenitor y2 allele is still present.

(Georgiev et al., 1997)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Body colour: wild-type pigmentation in the abdomen and bristles.

      (Pomerantseva et al., 2006)

      Body colour: homozygotes have wild-type pigmentation in the body cuticle and wing blade and in the thoracic, leg, wing and abdominal bristles.

      (Biryukova et al., 1999)

      Pigmentation of all cuticular structures is normal in hemizygous males. This phenotype is not altered by either mod(mdg4)ul or su(Hw)2.

      (Georgiev et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      y+s has abnormal body color | recessive phenotype, enhanceable by ph-pP1

      (Biryukova et al., 1999)
      Suppressed by
      Statement
      Reference

      ph-pP1, y+s has abnormal body color | recessive phenotype, suppressible by sneP1/sn[+]

      (Biryukova et al., 1999)

      ph-pP1, y+s has abnormal body color | recessive phenotype, suppressible by Su(y)P22P22/Su(y)P22[+]

      (Biryukova et al., 1999)

      ph-pP1, y+s has abnormal body color | recessive phenotype, suppressible by Su(y)P31[+]/Su(y)P31P31

      (Biryukova et al., 1999)

      ph-pP1, y+s has abnormal body color phenotype, suppressible by su(Hw)2

      (Biryukova et al., 1999)

      ph-pP1, y+s has abnormal body color phenotype, suppressible by su(Hw)V

      (Biryukova et al., 1999)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      y+s has wing phenotype, enhanceable by ph-pP1

      (Biryukova et al., 1999)

      y+s has adult thorax & macrochaeta phenotype, enhanceable by ph-pP1

      (Biryukova et al., 1999)

      y+s has leg sensillum phenotype, enhanceable by ph-pP1

      (Biryukova et al., 1999)

      y+s has adult abdomen & macrochaeta phenotype, enhanceable by ph-pP1

      (Biryukova et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In the presence of ph-pP1, pigmentation of the body cuticle and wing blade and thoracic, leg and abdominal bristles is reduced. This enhancement by ph-pP1 is completely suppressed by su(Hw)2/su(Hw)V.

      (Biryukova et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Highly unstable allele.

      (Georgiev et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      y+s1
      (Biryukova et al., 1999)
      y+s
      (Pomerantseva et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)