ctpexc3 mutant clones produce egg chambers with a 16 nurse cell phenotype. The synaptonemal complex is initially restricted to a single cell, but is not maintained beyond stage 1.
Homozygous embryos do not develop past stage 10. Degenerating embryos exhibit disorganised cellular morphology (degradation of genomic DNA) and cytoplasmic condensation and fragmentation, indication of programmed cell death. Homozygous ctpins1 females exhibit disorganisation of ovarioles and egg chambers, disorganisation is more severe when transheterozygous with ctpexc3.
ctpexc3 is a suppressor of partially lethal - majority die | embryonic stage phenotype of BicDD, stauunspecified
stauunspecified/ctpexc3 is a suppressor | partially of partially lethal - majority die | embryonic stage phenotype of BicDD
stauunspecified/ctpexc3 is a suppressor | partially of embryonic/first instar larval cuticle phenotype of BicDD
ctpexc3 is a suppressor of embryonic/first instar larval cuticle phenotype of BicDD, stauunspecified
BicDD stauunspecified / ctpexc3 triple mutants exhibit a 0.7% hatch-rate, compared to 0.25% in BicDD stauunspecified mutants. This indicates a mild suppression of the BicDD stauunspecified by ctpexc3. Removing one copy of ctpexc3 suppresses the 'double abdomen' phenotype of BicDD stauunspecified and allows more wild-type cuticle to form. The percentage of bicaudal decreases from 97% (BicDD stauunspecified) to 57% (BicDD stauunspecified/ctpexc3). This coincides with an increase in the number of asymmetric, headless and normal embryos.
BicDD/ctpexc3 double mutants exhibit a 39% hatch-rate, compared to 2% in BicDD mutants. This indicates suppression of the BicDD stauunspecified mutant phenotype by ctpexc3.
