FB2024_03 , released June 25, 2024
Allele: Dmel\Ubxlac1
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General Information
Symbol
Dmel\Ubxlac1
Species
D. melanogaster
Name
FlyBase ID
FBal0058030
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
P{A92}Ubxlac1
Carried in Construct
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Casares et al., 1996)

loss of function allele

(Casares et al., 1997)
Mutagen
Delta2-3 transposase
(Casares et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{A92}Ubxlac1
Cytology
Description

P{A92} in inserted into the first intron of Ubx, at coordinate -34kb of FBrf0040194. The Ecol\lacZ gene is transcribed in the opposite orientation to Ubx. Transcriptional analysis indicates that the Ubx transcripts initiate but do not continue to their proper 3' end.

(Casares et al., 1997)

P-element insertion in the Ubx gene.

(Casares et al., 1996)
Allele components
Component
Use(s)
Inserted element
P{A92}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Shows a bithorax phenotype over TM3 (which carries Ubxbx-34e).

      (Casares et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ubxabx-1 Ubxbx-3 Ubxpbx-1/Ubxlac1 combination transforms the metathorax into mesothorax (including transformation of halteres into wings). This phenotype can be rescued by Scer\GAL4Bx-MS1096 induced expression abd-A. Ectopic expression of Abd-B allows partial rescue.

      (Casares et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      UbxCbx-1RM/Ubxlac1 transheterozygotes can be rescued by Dp(3;1)P115.

      (Casares et al., 1997)

      Ubxabx-1 Ubxbx-3 Ubxpbx-1/Ubxlac1 combination transforms the metathorax into mesothorax (including transformation of halteres into wings). This phenotype can be rescued by Scer\GAL4Bx-MS1096 induced expression of Ubx.

      (Casares et al., 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Δ2-3-induced mobilization of the P{A92} insert causes reversions as well as generating different bithorax/postbithorax phenotypes from the original Ubxlac1 insertion.

      (Casares et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ubxlac1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)