FlyBase Allele Report: Dmel\fra[1]

General Information

Symbol

Dmel\fra¹

Species

D. melanogaster

Name

FlyBase ID

FBal0057436

Feature type

allele

Associated gene

Dmel\fra

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Kolodziej et al., 1996)

Mutagen

Delta2-3 transposase

(Kolodziej et al., 1996)

Progenitor genotype

fra^49B

(Kolodziej et al., 1996)

Caused by aberration

T(2;3)fra¹

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Kolodziej et al., 1996)

some die during embryonic stage | recessive

(Kolodziej et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Df(2R)en-SFX31, fra¹ has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^prd.RG1/fra^UAS.cKa

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has lethal | adult stage phenotype, suppressible by Scer\GAL4^prd.RG1/fra^UAS.cKa

(Joly et al., 2007)

NOT suppressed by

Statement

Reference

Df(2R)en-SFX31, fra¹ has abnormal neuroanatomy phenotype, non-suppressible by fra^UAS.cKa/Scer\GAL4^elav.PLu

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has lethal | adult stage phenotype, non-suppressible by fra^UAS.cKa/Scer\GAL4^elav.PLu

(Joly et al., 2007)

Other

Statement

Reference

Df(2R)en-SFX31, fra¹ has abnormal neuroanatomy phenotype

(Joly et al., 2007)

en^E, fra¹ has lethal | adult stage phenotype

(Joly et al., 2007)

en⁵⁴, fra¹ has abnormal neuroanatomy phenotype

(Joly et al., 2007)

en⁵⁴, fra¹ has lethal | adult stage phenotype

(Joly et al., 2007)

fra¹, inv³⁰ has abnormal neuroanatomy phenotype

(Joly et al., 2007)

fra¹, inv³⁰ has lethal | adult stage phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has lethal | adult stage phenotype

(Joly et al., 2007)

en^E, fra¹ has abnormal neuroanatomy phenotype

(Joly et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

Df(2R)en-SFX31, fra¹ has larval ventral nerve cord phenotype, suppressible by Scer\GAL4^prd.RG1/fra^UAS.cKa

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has larval posterior commissure phenotype, suppressible by Scer\GAL4^prd.RG1/fra^UAS.cKa

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has larval anterior commissure phenotype, suppressible by Scer\GAL4^prd.RG1/fra^UAS.cKa

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has lateral tract phenotype, suppressible by Scer\GAL4^prd.RG1/fra^UAS.cKa

(Joly et al., 2007)

NOT suppressed by

Statement

Reference

Df(2R)en-SFX31, fra¹ has larval ventral nerve cord phenotype, non-suppressible by fra^UAS.cKa/Scer\GAL4^elav.PLu

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has larval posterior commissure phenotype, non-suppressible by fra^UAS.cKa/Scer\GAL4^elav.PLu

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has larval anterior commissure phenotype, non-suppressible by fra^UAS.cKa/Scer\GAL4^elav.PLu

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has lateral tract phenotype, non-suppressible by fra^UAS.cKa/Scer\GAL4^elav.PLu

(Joly et al., 2007)

Other

Statement

Reference

Df(2R)en-SFX31, fra¹ has larval ventral nerve cord phenotype

(Joly et al., 2007)

en^E, fra¹ has lateral tract phenotype

(Joly et al., 2007)

en⁵⁴, fra¹ has larval ventral nerve cord phenotype

(Joly et al., 2007)

en⁵⁴, fra¹ has larval anterior commissure phenotype

(Joly et al., 2007)

en⁵⁴, fra¹ has larval posterior commissure phenotype

(Joly et al., 2007)

en⁵⁴, fra¹ has lateral tract phenotype

(Joly et al., 2007)

fra¹, inv³⁰ has larval ventral nerve cord phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has larval anterior commissure phenotype

(Joly et al., 2007)

fra¹, inv³⁰ has larval anterior commissure phenotype

(Joly et al., 2007)

fra¹, inv³⁰ has larval posterior commissure phenotype

(Joly et al., 2007)

fra¹, inv³⁰ has lateral tract phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has larval posterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, fra¹ has lateral tract phenotype

(Joly et al., 2007)

en^E, fra¹ has larval ventral nerve cord phenotype

(Joly et al., 2007)

en^E, fra¹ has larval anterior commissure phenotype

(Joly et al., 2007)

en^E, fra¹ has larval posterior commissure phenotype

(Joly et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Approximately 68% of fra¹/Df(2R)en-SFX31 double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Nearly all the segments are affected in these embryos. Approximately 91% of the axons that project through the posterior commissures of fra¹/Df(2R)en-SFX31 transheterozygotes do not grow properly, whereas only 12% of the axonal projections through the anterior commissures are affected.

Approximately 60% of fra¹/en^E double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Nearly all the segments are affected in these embryos.

Approximately 60.5% of fra¹/en⁵⁴ double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Nearly all the segments are affected in these embryos.

Approximately 34% of fra¹/inv³⁰ double mutants exhibit defects in axonal pathfinding. Stage 15 embryos display dramatic defects in ventral nerve cord architecture, with the posterior commissures missing or fused with the anterior commissures, and longitudinal tracts thinner. Approximately 87% of the segments are affected in these embryos.

Approximately 49% of fra¹/Df(2R)en-SFX31 double mutants are adult lethal.

Approximately 33% of fra¹/en⁵⁴ double mutants are adult lethal.

Approximately 15% of fra¹/inv³⁰ double mutants are adult lethal.

Expression of fra^Scer\UAS.cKa in the early stages of axon pathfinding under the control of Scer\GAL4^prd.RG1 rescues axonal defects in even segments of fra¹/Df(2R)en-SFX31 transheterozygous embryos. Approximately 60% of the segments display normal commissures, in contrast to fra¹/Df(2R)en-SFX31 embryos, in which nearly all the segments are affected. A partial rescue of odd segments is also seen. In contrast, overexpression of fra^Scer\UAS.cKa in later stages of development, under the control of Scer\GAL4^elav.PLu does not rescue the the defects in ventral nerve cord architecture seen in fra¹/Df(2R)en-SFX31 mutants.

(Joly et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fra¹

(Joly et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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