FB2024_03 , released June 25, 2024
Allele: Dmel\timSL
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General Information
Symbol
Dmel\timSL
Species
D. melanogaster
Name
suppressor of perL1
FlyBase ID
FBal0055980
Feature type
allele
Associated gene
Dmel\tim
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Rutila et al., 1996)
Progenitor genotype
Cytology
Description

Amino acid replacement: T494I. Nucleotide substitution: C1724T.

(Rutila et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:3,502,832..3,502,832 [-]
Nucleotide change:

C3502832T

Reported nucleotide change:

C1724T

Amino acid change:

T503I | tim-PB; T503I | tim-PL; T503I | tim-PM; T503I | tim-PN; T503I | tim-PO; T503I | tim-PP; T471I | tim-PR; T471I | tim-PS; T526I | tim-PT; T503I | tim-PU

Reported amino acid change:

T494I

(Rutila et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies show an increased light sensitivity of locomotor activity phase shifting compared to wild-type flies.

      (Suri et al., 1998)

      Mutation can shorten the wild type period by half an hour.

      (Rutila et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      timSL is a suppressor of phenotype of perL1

      (Rutila et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mutation can shorten the circadian period of perL1 from 29 to 26 hours (and similarly the perLR period from 28 to 25 hours) and increase the period of pers by an hour. Mutation can also shorten the time of perL1 eclosion.

      (Rutila et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      elvis
      (Rutila et al., 1996, Rutila et al., 1995)
      suppressor of perL
      (Stanewsky, 2003)
      timSL
      Name Synonyms
      suppressor of perL1
      (Rutila et al., 1996)
      Secondary FlyBase IDs
        References (7)